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Conference Paper: A role of interleukin-17A in modulating intracellular survival of mycobacterium bovis BCG in murine macrophages
| Title | A role of interleukin-17A in modulating intracellular survival of mycobacterium bovis BCG in murine macrophages |
|---|---|
| Authors | |
| Issue Date | 2013 |
| Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
| Citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, , v. 18 n. 4, p. 250 How to Cite? |
| Abstract | Interleukin-17A (IL-17A) has been demonstrated to
participate in a range of autoimmune diseases and
infections. Whether IL-17A regulates innate defense
mechanisms of macrophage against mycobacteria remain
to be investigated. In this study, we investigated the effects
of IL-17A on modulating the intracellular survival of
Mycobacterium bovis BCG in RAW264.7 macrophages.
We first observed that IL-17A pretreatment was able to
synergistically enhance both nitric oxide (NO) production
and inducible nitric oxide synthase (iNOS) expression in
BCG-infected macrophages in dose- and time-dependent
manner. Mechanistically, we found that IL-17A was able Interleukin-17A (IL-17A) has been demonstrated to
participate in a range of autoimmune diseases and
infections. Whether IL-17A regulates innate defense
mechanisms of macrophage against mycobacteria remain
to be investigated. In this study, we investigated the effects
of IL-17A on modulating the intracellular survival of
Mycobacterium bovis BCG in RAW264.7 macrophages.
We first observed that IL-17A pretreatment was able to
synergistically enhance both nitric oxide (NO) production
and inducible nitric oxide synthase (iNOS) expression in
BCG-infected macrophages in dose- and time-dependent
manner. Mechanistically, we found that IL-17A was able |
| Description | Poster Presentation (Doctor’s Session) Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf |
| Persistent Identifier | http://hdl.handle.net/10722/206042 |
| ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ling, WL | en_US |
| dc.contributor.author | Wang, L | en_US |
| dc.contributor.author | Pong, CH | en_US |
| dc.contributor.author | Lau, ASY | en_US |
| dc.contributor.author | Li, CB | en_US |
| dc.date.accessioned | 2014-10-20T11:47:22Z | - |
| dc.date.available | 2014-10-20T11:47:22Z | - |
| dc.date.issued | 2013 | en_US |
| dc.identifier.citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, , v. 18 n. 4, p. 250 | en_US |
| dc.identifier.issn | 1013-9923 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/206042 | - |
| dc.description | Poster Presentation (Doctor’s Session) | - |
| dc.description | Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf | - |
| dc.description.abstract | Interleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able Interleukin-17A (IL-17A) has been demonstrated to participate in a range of autoimmune diseases and infections. Whether IL-17A regulates innate defense mechanisms of macrophage against mycobacteria remain to be investigated. In this study, we investigated the effects of IL-17A on modulating the intracellular survival of Mycobacterium bovis BCG in RAW264.7 macrophages. We first observed that IL-17A pretreatment was able to synergistically enhance both nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BCG-infected macrophages in dose- and time-dependent manner. Mechanistically, we found that IL-17A was able | - |
| dc.language | eng | en_US |
| dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | - |
| dc.relation.ispartof | Hong Kong Journal of Paediatrics (New series) | en_US |
| dc.title | A role of interleukin-17A in modulating intracellular survival of mycobacterium bovis BCG in murine macrophages | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Ling, WL: lingwl@graduate.hku.hk | en_US |
| dc.identifier.email | Wang, L: vickyw@hku.hk | en_US |
| dc.identifier.email | Pong, CH: jchpong@hku.hk | en_US |
| dc.identifier.email | Lau, ASY: asylau@hku.hk | en_US |
| dc.identifier.email | Li, CB: jamesli@graduate.hku.hk | en_US |
| dc.identifier.authority | Lau, ASY=rp00474 | en_US |
| dc.identifier.authority | Li, CB=rp00496 | en_US |
| dc.identifier.hkuros | 241315 | en_US |
| dc.identifier.volume | 18 | - |
| dc.identifier.issue | 4 | - |
| dc.identifier.spage | 250 | - |
| dc.identifier.epage | 250 | - |
| dc.publisher.place | Hong Kong | - |
| dc.identifier.issnl | 1013-9923 | - |