File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Regulation of HIV-Tat induced cytokine expression and consequent opportunistic infection by the proto-oncogene c-Myc
Title | Regulation of HIV-Tat induced cytokine expression and consequent opportunistic infection by the proto-oncogene c-Myc |
---|---|
Authors | |
Issue Date | 2013 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 234 How to Cite? |
Abstract | Human immunodeficiency virus (HIV) remains a major
health problem around the globe, especially in third world
countries where acquired immunodeficiency syndrome
(AIDS) is highly prevalent and currently incurable. The
HIV-1 trans-activator (Tat) protein is an important viral
protein that is known to contribute to the AIDS pathogenesis
via the dysregulation of cytokines such as TNF-α and IL-
6. In this study, we recognised that c-Myc, a proto-oncogene
known to regulate a wide range of cellular process, also
regulated primary blood derived macrophage (PBMac)
immune response induced by HIV-1 Tat. We first found
that HIV-1 Tat could induce the expression of c-Myc.The
function and expression of HIV- 1 Tat induced c-Myc was
subsequently found to be regulated through the activation
of the dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). Inhibition
of c-Myc expression in turn demonstrated that c-Myc may
be essential for the up-regulation of the pro-inflammatory
cytokines TNF-α and IL-6 by HIV-1 Tat. Furthermore,
c-Myc regulation of HIV-1 Tat induced cytokine expression
consequently affected the intracellular survival of the
opportunistic microbe, Mycobacteria avium intracellulare,
in PBMac. Taken together, we demonstrated that c-Myc
may play a significant role in the pathogenesis of AIDS,
by mediating the dysregulation of cytokine expression
induced by Tat and possibly accentuate opportunistic
infection. |
Description | Oral Presentation (Doctor’s Session) Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf |
Persistent Identifier | http://hdl.handle.net/10722/206041 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pong, CH | en_US |
dc.contributor.author | Li, CB | en_US |
dc.contributor.author | Lau, ASY | en_US |
dc.date.accessioned | 2014-10-20T11:47:20Z | - |
dc.date.available | 2014-10-20T11:47:20Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 234 | en_US |
dc.identifier.issn | 1013-9923 | - |
dc.identifier.uri | http://hdl.handle.net/10722/206041 | - |
dc.description | Oral Presentation (Doctor’s Session) | - |
dc.description | Fulltext in: http://www.hkjpaed.org/pdf/2013;18;230-265.pdf | - |
dc.description.abstract | Human immunodeficiency virus (HIV) remains a major health problem around the globe, especially in third world countries where acquired immunodeficiency syndrome (AIDS) is highly prevalent and currently incurable. The HIV-1 trans-activator (Tat) protein is an important viral protein that is known to contribute to the AIDS pathogenesis via the dysregulation of cytokines such as TNF-α and IL- 6. In this study, we recognised that c-Myc, a proto-oncogene known to regulate a wide range of cellular process, also regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. We first found that HIV-1 Tat could induce the expression of c-Myc.The function and expression of HIV- 1 Tat induced c-Myc was subsequently found to be regulated through the activation of the dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). Inhibition of c-Myc expression in turn demonstrated that c-Myc may be essential for the up-regulation of the pro-inflammatory cytokines TNF-α and IL-6 by HIV-1 Tat. Furthermore, c-Myc regulation of HIV-1 Tat induced cytokine expression consequently affected the intracellular survival of the opportunistic microbe, Mycobacteria avium intracellulare, in PBMac. Taken together, we demonstrated that c-Myc may play a significant role in the pathogenesis of AIDS, by mediating the dysregulation of cytokine expression induced by Tat and possibly accentuate opportunistic infection. | - |
dc.language | eng | en_US |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | - |
dc.relation.ispartof | Hong Kong Journal of Paediatrics (New series) | en_US |
dc.title | Regulation of HIV-Tat induced cytokine expression and consequent opportunistic infection by the proto-oncogene c-Myc | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Pong, CH: jchpong@hku.hk | en_US |
dc.identifier.email | Li, CB: jamesli@graduate.hku.hk | en_US |
dc.identifier.email | Lau, ASY: asylau@hku.hk | en_US |
dc.identifier.authority | Li, CB=rp00496 | en_US |
dc.identifier.authority | Lau, ASY=rp00474 | en_US |
dc.identifier.hkuros | 241312 | en_US |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 234 | - |
dc.identifier.epage | 234 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1013-9923 | - |