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Article: Validation and application of health utilities index in Chinese subjects with Down Syndrome

TitleValidation and application of health utilities index in Chinese subjects with Down Syndrome
Authors
KeywordsChinese
Chronic health conditions
Down syndrome
Health utility index
Health-related quality of life
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.hqlo.com/home/
Citation
Health and Quality of Life Outcomes, 2014, v. 12 n. 1, p. 144 How to Cite?
AbstractObjectives: The objectives of the study were (1) to validate the Chinese version of Health Utilities Index (HUI-Ch); (2) to examine the Health-related Quality of Life (HRQoL) of Chinese subjects with Down syndrome (DS); and (3) to study the impact of chronic health conditions on HRQoL of Chinese with DS. Methods: The multiple choice questionnaire for scoring Health Utilities Index Mark 2 (HUI2) and Health Utilities Index Mark 3 (HUI3) was translated and validated. In addition to the HRQoL scores from HUI2 and HUI3, proxy-data on socio-demographics, and 10 common chronic health conditions for people with DS were collected and analyzed. Data analysis involves multiple imputation and multiple regression analysis to predict variations in HRQoL in relation to different factors. Lastly, a gradient interval was constructed on the number of chronic health conditions in relation to HRQoL. Results: HUI-Ch was validated according to standard guidelines. People with DS were found to have a lower HRQoL as compared to the general population, with the majority categorized as moderate or severe on the scale. Behavioral and hearing problems on HUI2, and hearing problems on HUI3 were found to be statistically significant predictors of a lower HRQoL score. A significant gradient relationship existed showing when the number of health problems increased, the HRQoL scores decreased. Conclusions: HUI-Ch is a valid instrument to assess HRQoL. It can have broad application in Chinese subjects with DS including the study of the impact of different chronic health conditions on their quality of life. The quantifiable nature of HUI-Ch will facilitate longitudinal study on the well-being of subjects with DS and evaluation of effectiveness of intervention programs in the near future.
Persistent Identifierhttp://hdl.handle.net/10722/205944
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.140
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMok, WKY-
dc.contributor.authorWong, WHS-
dc.contributor.authorMok, TKG-
dc.contributor.authorChu, WY-
dc.contributor.authorHo, KW-
dc.contributor.authorChow, CB-
dc.contributor.authorIp, P-
dc.contributor.authorChung, BHY-
dc.date.accessioned2014-10-20T10:13:39Z-
dc.date.available2014-10-20T10:13:39Z-
dc.date.issued2014-
dc.identifier.citationHealth and Quality of Life Outcomes, 2014, v. 12 n. 1, p. 144-
dc.identifier.issn1477-7525-
dc.identifier.urihttp://hdl.handle.net/10722/205944-
dc.description.abstractObjectives: The objectives of the study were (1) to validate the Chinese version of Health Utilities Index (HUI-Ch); (2) to examine the Health-related Quality of Life (HRQoL) of Chinese subjects with Down syndrome (DS); and (3) to study the impact of chronic health conditions on HRQoL of Chinese with DS. Methods: The multiple choice questionnaire for scoring Health Utilities Index Mark 2 (HUI2) and Health Utilities Index Mark 3 (HUI3) was translated and validated. In addition to the HRQoL scores from HUI2 and HUI3, proxy-data on socio-demographics, and 10 common chronic health conditions for people with DS were collected and analyzed. Data analysis involves multiple imputation and multiple regression analysis to predict variations in HRQoL in relation to different factors. Lastly, a gradient interval was constructed on the number of chronic health conditions in relation to HRQoL. Results: HUI-Ch was validated according to standard guidelines. People with DS were found to have a lower HRQoL as compared to the general population, with the majority categorized as moderate or severe on the scale. Behavioral and hearing problems on HUI2, and hearing problems on HUI3 were found to be statistically significant predictors of a lower HRQoL score. A significant gradient relationship existed showing when the number of health problems increased, the HRQoL scores decreased. Conclusions: HUI-Ch is a valid instrument to assess HRQoL. It can have broad application in Chinese subjects with DS including the study of the impact of different chronic health conditions on their quality of life. The quantifiable nature of HUI-Ch will facilitate longitudinal study on the well-being of subjects with DS and evaluation of effectiveness of intervention programs in the near future.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.hqlo.com/home/-
dc.relation.ispartofHealth and Quality of Life Outcomes-
dc.rightsHealth and Quality of Life Outcomes. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChinese-
dc.subjectChronic health conditions-
dc.subjectDown syndrome-
dc.subjectHealth utility index-
dc.subjectHealth-related quality of life-
dc.titleValidation and application of health utilities index in Chinese subjects with Down Syndrome-
dc.typeArticle-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailMok, TKG: gtkmok@hku.hk-
dc.identifier.emailChu, WY: chuwyy@hku.hk-
dc.identifier.emailChow, CB: chowcb@hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailChung, BHY: bhychung@hku.hk-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityChung, BHY=rp00473-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12955-014-0144-x-
dc.identifier.pmid25311245-
dc.identifier.pmcidPMC4207901-
dc.identifier.scopuseid_2-s2.0-84964316162-
dc.identifier.hkuros241022-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spage144-
dc.identifier.epage144-
dc.identifier.isiWOS:000345353700001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1477-7525-

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