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Article: Dynamic development of regional cortical thickness and surface area in early childhood

TitleDynamic development of regional cortical thickness and surface area in early childhood
Authors
Keywordsbrain development
cerebral cortex
gray matter
human
magnetic resonance imaging
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/
Citation
Cerebral Cortex, 2015, v. 25 n. 8, p. 2204-2212 How to Cite?
AbstractCortical thickness (CT) and surface area (SA) are altered in many neuropsychiatric disorders and are correlated with cognitive func- tioning. Little is known about how these components of cortical gray matter develop in the first years of life. We studied the longitudinal development of regional CT and SA expansion in healthy infants from birth to 2 years. CT and SA have distinct and heterogeneous patterns of development that are exceptionally dynamic; overall CT increases by an average of 36.1%, while cortical SA increases 114.6%. By age 2, CT is on average 97% of adult values, compared with SA, which is 69%. This suggests that early identification, prevention, and interven- tion strategies for neuropsychiatric illness need to be targeted to this period of rapid postnatal brain development, and that SA expansion is the principal driving factor in cortical volume after 2 years of age.
DescriptionLink to Free access
Persistent Identifierhttp://hdl.handle.net/10722/204956
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 1.685
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLyall, AE-
dc.contributor.authorShi, F-
dc.contributor.authorGeng, X-
dc.contributor.authorWoolson, S-
dc.contributor.authorLi, G-
dc.contributor.authorWang, L-
dc.contributor.authorHamer, RM-
dc.contributor.authorShen, D-
dc.contributor.authorGilmore, JH-
dc.date.accessioned2014-09-20T01:14:17Z-
dc.date.available2014-09-20T01:14:17Z-
dc.date.issued2015-
dc.identifier.citationCerebral Cortex, 2015, v. 25 n. 8, p. 2204-2212-
dc.identifier.issn1047-3211-
dc.identifier.urihttp://hdl.handle.net/10722/204956-
dc.descriptionLink to Free access-
dc.description.abstractCortical thickness (CT) and surface area (SA) are altered in many neuropsychiatric disorders and are correlated with cognitive func- tioning. Little is known about how these components of cortical gray matter develop in the first years of life. We studied the longitudinal development of regional CT and SA expansion in healthy infants from birth to 2 years. CT and SA have distinct and heterogeneous patterns of development that are exceptionally dynamic; overall CT increases by an average of 36.1%, while cortical SA increases 114.6%. By age 2, CT is on average 97% of adult values, compared with SA, which is 69%. This suggests that early identification, prevention, and interven- tion strategies for neuropsychiatric illness need to be targeted to this period of rapid postnatal brain development, and that SA expansion is the principal driving factor in cortical volume after 2 years of age.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/-
dc.relation.ispartofCerebral Cortex-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectbrain development-
dc.subjectcerebral cortex-
dc.subjectgray matter-
dc.subjecthuman-
dc.subjectmagnetic resonance imaging-
dc.titleDynamic development of regional cortical thickness and surface area in early childhood-
dc.typeArticle-
dc.identifier.emailGeng, X: gengx@hku.hk-
dc.identifier.authorityGeng, X=rp01678-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/cercor/bhu027-
dc.identifier.scopuseid_2-s2.0-84938604195-
dc.identifier.hkuros239144-
dc.identifier.volume25-
dc.identifier.issue8-
dc.identifier.spage2204-
dc.identifier.epage2212-
dc.identifier.isiWOS:000359320000018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1047-3211-

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