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Conference Paper: Drug utilisation patterns in hospitalised children: An international perspective
Title | Drug utilisation patterns in hospitalised children: An international perspective |
---|---|
Authors | |
Keywords | drug utilisation paediatric international |
Issue Date | 2013 |
Publisher | The Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62 |
Citation | The 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 140 How to Cite? |
Abstract | Aim/Objective: The majority of published drug utilisation studies in children come from primary care. Our aim was to investigate
and compare patterns of drug therapy in hospitalised children in fi ve European and Non-European countries using a standardised
protocol and terminologies.
Methods: A prospective cohort study was conducted on paediatric medical wards in UK, Germany, Australia, Hong Kong (HK), and
Malaysia. Drugs prescribed were classifi ed using WHO Anatomical Therapeutic Chemical (ATC) classifi cation. The frequency of
prescriptions and exposure rates were calculated at ATC anatomic and therapeutic levels overall and stratifi ed by country.
Results: 1278 patients were included (Australia 146, Germany 376, UK 313, HK 143, Malaysia 300). 1140 patients (89.2%)
received 5367 prescriptions, median 3 per patient (IQR 2-5).
The three most frequently prescribed therapeutic groups were; systemic antibacterials [1355 (25.3%), exposure (65.1%)], analgesics/
NSAIDs [1172 (21.8%), exposure (63.6%)], ‘drugs for obstructive airway diseases’ [472 (8.8%), exposure (23.6%)]. Number of
patients exposed to these groups differed signifi cantly between countries p<0.05. Patients’ exposure to systemic antibacterials
was highest in Malaysia (84.7%), lowest in HK (37.1%). Patients’ exposure to analgesics/NSAIDs varied signifi cantly between
countries being highest in UK (84.2%,) and lowest in HK (35,3%), p<0.001. Paracetamol was the most frequent analgesic/NSAID in
4 countries. Metamizol was only prescribed in Germany whereas morphine was predominantly prescribed in the UK.
Conclusion: This study shows that there are similarities but also signifi cant differences in drug utilisation patterns in hospitalised
children across countries. Rational drug therapy has to be further investigated and promoted in paediatric medicine. |
Description | Conference Theme: Applying pharmacoepidemiology to improve health care in Asia Oral Presentation - Genetics, Pregnancy and Paediatric Issues |
Persistent Identifier | http://hdl.handle.net/10722/204451 |
ISSN |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rashed, AN | en_US |
dc.contributor.author | Wilton, L | en_US |
dc.contributor.author | Tomlin, S | en_US |
dc.contributor.author | Wong, ICK | en_US |
dc.contributor.author | Neubert, A | en_US |
dc.date.accessioned | 2014-09-19T23:52:22Z | - |
dc.date.available | 2014-09-19T23:52:22Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 8th Asian Conference on Pharmacoepidemiology (ACPE 2013), Hong Kong, China, 25-27 October 2013. In Hong Kong Pharmaceutical Journal, 2013, v. 20 n. 3, p. 140 | en_US |
dc.identifier.issn | 1727-2874 | - |
dc.identifier.uri | http://hdl.handle.net/10722/204451 | - |
dc.description | Conference Theme: Applying pharmacoepidemiology to improve health care in Asia | - |
dc.description | Oral Presentation - Genetics, Pregnancy and Paediatric Issues | - |
dc.description.abstract | Aim/Objective: The majority of published drug utilisation studies in children come from primary care. Our aim was to investigate and compare patterns of drug therapy in hospitalised children in fi ve European and Non-European countries using a standardised protocol and terminologies. Methods: A prospective cohort study was conducted on paediatric medical wards in UK, Germany, Australia, Hong Kong (HK), and Malaysia. Drugs prescribed were classifi ed using WHO Anatomical Therapeutic Chemical (ATC) classifi cation. The frequency of prescriptions and exposure rates were calculated at ATC anatomic and therapeutic levels overall and stratifi ed by country. Results: 1278 patients were included (Australia 146, Germany 376, UK 313, HK 143, Malaysia 300). 1140 patients (89.2%) received 5367 prescriptions, median 3 per patient (IQR 2-5). The three most frequently prescribed therapeutic groups were; systemic antibacterials [1355 (25.3%), exposure (65.1%)], analgesics/ NSAIDs [1172 (21.8%), exposure (63.6%)], ‘drugs for obstructive airway diseases’ [472 (8.8%), exposure (23.6%)]. Number of patients exposed to these groups differed signifi cantly between countries p<0.05. Patients’ exposure to systemic antibacterials was highest in Malaysia (84.7%), lowest in HK (37.1%). Patients’ exposure to analgesics/NSAIDs varied signifi cantly between countries being highest in UK (84.2%,) and lowest in HK (35,3%), p<0.001. Paracetamol was the most frequent analgesic/NSAID in 4 countries. Metamizol was only prescribed in Germany whereas morphine was predominantly prescribed in the UK. Conclusion: This study shows that there are similarities but also signifi cant differences in drug utilisation patterns in hospitalised children across countries. Rational drug therapy has to be further investigated and promoted in paediatric medicine. | - |
dc.language | eng | en_US |
dc.publisher | The Pharmaceutical Society of Hong Kong. The Journal's web site is located at http://www.pshk.hk/main.php?id=62 | - |
dc.relation.ispartof | Hong Kong Pharmaceutical Journal | en_US |
dc.subject | drug utilisation | - |
dc.subject | paediatric | - |
dc.subject | international | - |
dc.title | Drug utilisation patterns in hospitalised children: An international perspective | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wong, ICK: wongick@hku.hk | en_US |
dc.identifier.authority | Wong, ICK=rp01480 | en_US |
dc.identifier.hkuros | 239877 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 140 | en_US |
dc.identifier.epage | 140 | en_US |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1727-2874 | - |