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Conference Paper: Is Disc Degeneration Painful?
Title | Is Disc Degeneration Painful? |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | Georg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53 |
Citation | World Forum for Spine Research (WFSR), Xi'an, China,15-17 May 2014. In Global Spine Journal, 2014, v. 4 n. Suppl. 1, p. S142-S143, abstract no. IN2.02 How to Cite? |
Abstract | affecting every population. Although LBP can be multifactorial,
disc degeneration has been suggested to be a determinant.
Disc degeneration is characterized by chemical and morphological
changes to the disc, which may usher in changes to its
biomechanics, interplay with the endplates and subchondral
bone, and may lead to an inflammatory response that can
irritate invading nerve fibers. Such changes to the disc and its
surrounding area may contribute to pain generation, whose
duration and intensity is uncertain. However, a divide is
present in epidemiological studies regarding the association
of disc degeneration and LBP, leading to the conclusion that
disc degeneration is not always synonymous with LBP. This
could be attributed to study design, inadequate statistical
analyses, and phenotyping issues of degenerative spine
changes as well as LBP. In addition, throughout the years,
advances in medical imaging have helped broaden the understanding of disc degeneration and imaging pain generators as
well the predictive utility of such imaging for future pain
development/severity. The evolution of pain genetics research
has provided further understanding why some individuals
may be more likely to experience pain than others in the
setting of degenerative spine changes. Further attention to the
phenotyping of spine degeneration has noted that patterns of
spine changes may play a role in LBP. The field of OMICSepidemiology
and the identification of additional biomarkers
(e.g., metabolomics, adipokines, etc.) could further broaden
the understanding between the association of disc degeneration
and LBP. In addition, the phenotyping of disc degeneration
requires further attention, demanding revisitation and
reclassification of long-held classification schemes as well as
being conscious of a direct link to their clinical relevance. A
global standardization of disc degeneration and LBP is needed
to help facilitate the collaboration of large-scale consortiums
to address such salient spine-related concerns. Disclosure of Interest
None declared |
Description | Conference theme: The Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation Invited Presentation The abstract can be viewed at http://www.spineresearchforum.org/WFSR_2014_Thieme_AbstractBook_with_Cover.pdf |
Persistent Identifier | http://hdl.handle.net/10722/204387 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.264 |
DC Field | Value | Language |
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dc.contributor.author | Samartzis, D | en_US |
dc.date.accessioned | 2014-09-19T22:41:29Z | - |
dc.date.available | 2014-09-19T22:41:29Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | World Forum for Spine Research (WFSR), Xi'an, China,15-17 May 2014. In Global Spine Journal, 2014, v. 4 n. Suppl. 1, p. S142-S143, abstract no. IN2.02 | en_US |
dc.identifier.issn | 2192-5682 | - |
dc.identifier.uri | http://hdl.handle.net/10722/204387 | - |
dc.description | Conference theme: The Intervertebral Disc - from Degeneration to Therapeutic Motion Preservation | - |
dc.description | Invited Presentation | - |
dc.description | The abstract can be viewed at http://www.spineresearchforum.org/WFSR_2014_Thieme_AbstractBook_with_Cover.pdf | - |
dc.description.abstract | affecting every population. Although LBP can be multifactorial, disc degeneration has been suggested to be a determinant. Disc degeneration is characterized by chemical and morphological changes to the disc, which may usher in changes to its biomechanics, interplay with the endplates and subchondral bone, and may lead to an inflammatory response that can irritate invading nerve fibers. Such changes to the disc and its surrounding area may contribute to pain generation, whose duration and intensity is uncertain. However, a divide is present in epidemiological studies regarding the association of disc degeneration and LBP, leading to the conclusion that disc degeneration is not always synonymous with LBP. This could be attributed to study design, inadequate statistical analyses, and phenotyping issues of degenerative spine changes as well as LBP. In addition, throughout the years, advances in medical imaging have helped broaden the understanding of disc degeneration and imaging pain generators as well the predictive utility of such imaging for future pain development/severity. The evolution of pain genetics research has provided further understanding why some individuals may be more likely to experience pain than others in the setting of degenerative spine changes. Further attention to the phenotyping of spine degeneration has noted that patterns of spine changes may play a role in LBP. The field of OMICSepidemiology and the identification of additional biomarkers (e.g., metabolomics, adipokines, etc.) could further broaden the understanding between the association of disc degeneration and LBP. In addition, the phenotyping of disc degeneration requires further attention, demanding revisitation and reclassification of long-held classification schemes as well as being conscious of a direct link to their clinical relevance. A global standardization of disc degeneration and LBP is needed to help facilitate the collaboration of large-scale consortiums to address such salient spine-related concerns. Disclosure of Interest None declared | - |
dc.language | eng | en_US |
dc.publisher | Georg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53 | - |
dc.relation.ispartof | Global Spine Journal | en_US |
dc.rights | Global Spine Journal. Copyright © Georg Thieme Verlag. | - |
dc.title | Is Disc Degeneration Painful? | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Samartzis, D: dspine@hku.hk | en_US |
dc.identifier.authority | Samartzis, D=rp01430 | en_US |
dc.identifier.hkuros | 238039 | en_US |
dc.identifier.volume | 4 | - |
dc.identifier.issue | Suppl. 1 | - |
dc.identifier.spage | S142, abstract no. IN2.02 | - |
dc.identifier.epage | S143, abstract no. IN2.02 | - |
dc.publisher.place | Germany | en_US |
dc.identifier.issnl | 2192-5682 | - |