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Conference Paper: Development of Serine/Threonine Ligation (STL) and its applications in the synthesis of proteins and cyclic peptides
Title | Development of Serine/Threonine Ligation (STL) and its applications in the synthesis of proteins and cyclic peptides |
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Authors | |
Issue Date | 2013 |
Publisher | The Symposium |
Citation | The 4th Modern Solid Phase Peptide Synthesis and Its Applications Symposium, Kobe, Japan, 2 November 2013. How to Cite? |
Abstract | Chemical ligation which couples side-chain unprotected peptide segments has become an attractive tool in the convergent peptide and protein synthesis. In line with the development of peptide ligation methods, our laboratory has recently described the use of a peptidyl salicylaldehyde (SAL) ester reacting with an N-terminal serine or threonine residue followed by acidolysis to generate a natural peptidic bond at the ligation site. We have demonstrated the effectiveness of this method with the synthesis of proteins and cyclic peptides. |
Description | Session 5: SP Protein Synthesis: no. 19 Solid Phase 2013 is an official satellite of the 4th Asia-Pacific International Peptide Symposium, which will be held in Kobe, Japan from 2-4 November 2013. |
Persistent Identifier | http://hdl.handle.net/10722/203969 |
DC Field | Value | Language |
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dc.contributor.author | Li, XC | en_US |
dc.date.accessioned | 2014-09-19T19:31:01Z | - |
dc.date.available | 2014-09-19T19:31:01Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 4th Modern Solid Phase Peptide Synthesis and Its Applications Symposium, Kobe, Japan, 2 November 2013. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/203969 | - |
dc.description | Session 5: SP Protein Synthesis: no. 19 | - |
dc.description | Solid Phase 2013 is an official satellite of the 4th Asia-Pacific International Peptide Symposium, which will be held in Kobe, Japan from 2-4 November 2013. | - |
dc.description.abstract | Chemical ligation which couples side-chain unprotected peptide segments has become an attractive tool in the convergent peptide and protein synthesis. In line with the development of peptide ligation methods, our laboratory has recently described the use of a peptidyl salicylaldehyde (SAL) ester reacting with an N-terminal serine or threonine residue followed by acidolysis to generate a natural peptidic bond at the ligation site. We have demonstrated the effectiveness of this method with the synthesis of proteins and cyclic peptides. | - |
dc.language | eng | en_US |
dc.publisher | The Symposium | - |
dc.relation.ispartof | Solid Phase 2013 | en_US |
dc.title | Development of Serine/Threonine Ligation (STL) and its applications in the synthesis of proteins and cyclic peptides | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Li, XC: xuechenl@hku.hk | en_US |
dc.identifier.authority | Li, XC=rp00742 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 240358 | en_US |