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Conference Paper: Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway
| Title | Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 11 How to Cite? |
| Abstract | Craniofacial anomalies are common features of Branchio-Oto-Renal (BOR) syndrome patients. Mutations in the Eya1 gene have been found in around half of the BOR patients, but the pathogenic mechanisms mediated by Eya1 in the craniofacial malformations remain unknown. In this study, we use Eya1 mutant mice as a disease model to study the abnormal early branchial arch (BA) development. Eya1-/- mutant embryos have hypoplastic BA2. The formation of branchial cleft was severely affected. Interestingly, Notch signaling was down-regulated in the mutant branchial ... |
| Description | Student Oral Presentation Session 3 |
| Persistent Identifier | http://hdl.handle.net/10722/203832 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, H | en_US |
| dc.contributor.author | Sham, MH | en_US |
| dc.date.accessioned | 2014-09-19T16:41:15Z | - |
| dc.date.available | 2014-09-19T16:41:15Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 11 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/203832 | - |
| dc.description | Student Oral Presentation Session 3 | - |
| dc.description.abstract | Craniofacial anomalies are common features of Branchio-Oto-Renal (BOR) syndrome patients. Mutations in the Eya1 gene have been found in around half of the BOR patients, but the pathogenic mechanisms mediated by Eya1 in the craniofacial malformations remain unknown. In this study, we use Eya1 mutant mice as a disease model to study the abnormal early branchial arch (BA) development. Eya1-/- mutant embryos have hypoplastic BA2. The formation of branchial cleft was severely affected. Interestingly, Notch signaling was down-regulated in the mutant branchial ... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Hong Kong Inter-University 2014 Biochemistry Postgraduate Symposium | en_US |
| dc.title | Eya1 is essential for branchial arch segmentation and branchial epithelium development through regulating Notch signaling pathway | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Sham, MH: mhsham@hku.hk | en_US |
| dc.identifier.authority | Sham, MH=rp00380 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 240239 | en_US |
| dc.identifier.hkuros | 270426 | - |
| dc.identifier.spage | 11 | - |
| dc.identifier.epage | 11 | - |