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Conference Paper: Timeless interacts with Parp1 to promote homologous recombination repair

TitleTimeless interacts with Parp1 to promote homologous recombination repair
Authors
Xie, SMortuewicz, OMa, KPoon, RHelleday, TQian, C
Issue Date2014
Citation
The 2014 Gordon Research Conference on Genomic Instability, The Hong Kong University of Science and Technology, Hong Kong, 6-11 July 2014. How to Cite?
AbstractBoth Parp1 and Timeless have been implicated in DNA damage response, while there is no report that Parp1 could function together with Timeless. We have, for the first time, provided the evidence that Parp1 binds to Timeless both in vitro and in vivo. In addition, we present the crystal structure of Timeless in complex with Parp1, and demonstrate that Timeless-Parp1 complex facilitates homologous recombination repair.
DescriptionConference Theme: Mechanisms That Cause DNA Damage and Related Diseases
Persistent Identifierhttp://hdl.handle.net/10722/203757

 

DC FieldValueLanguage
dc.contributor.authorXie, Sen_US
dc.contributor.authorMortuewicz, Oen_US
dc.contributor.authorMa, Ken_US
dc.contributor.authorPoon, Ren_US
dc.contributor.authorHelleday, Ten_US
dc.contributor.authorQian, Cen_US
dc.date.accessioned2014-09-19T16:40:52Z-
dc.date.available2014-09-19T16:40:52Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Gordon Research Conference on Genomic Instability, The Hong Kong University of Science and Technology, Hong Kong, 6-11 July 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/203757-
dc.descriptionConference Theme: Mechanisms That Cause DNA Damage and Related Diseases-
dc.description.abstractBoth Parp1 and Timeless have been implicated in DNA damage response, while there is no report that Parp1 could function together with Timeless. We have, for the first time, provided the evidence that Parp1 binds to Timeless both in vitro and in vivo. In addition, we present the crystal structure of Timeless in complex with Parp1, and demonstrate that Timeless-Parp1 complex facilitates homologous recombination repair.en_US
dc.languageengen_US
dc.relation.ispartofGordon Research Conference on Genomic Instabilityen_US
dc.titleTimeless interacts with Parp1 to promote homologous recombination repairen_US
dc.typeConference_Paperen_US
dc.identifier.emailQian, C: cmqian@hku.hken_US
dc.identifier.authorityQian, C=rp01371en_US
dc.identifier.hkuros237290en_US
dc.identifier.hkuros237297-

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