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- Publisher Website: 10.1039/c3cc45360j
- Scopus: eid_2-s2.0-84884193708
- PMID: 23962988
- WOS: WOS:000324490200018
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Article: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1
Title | Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1 |
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Authors | |
Issue Date | 2013 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp |
Citation | Chemical Communications, 2013, v. 49 n. 80, p. 9134-9136 How to Cite? |
Abstract | The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (logK = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter. © 2013 The Royal Society of Chemistry. |
Persistent Identifier | http://hdl.handle.net/10722/202606 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.133 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Du, X | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Liu, Q | - |
dc.contributor.author | Ni, J | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2014-09-19T08:42:28Z | - |
dc.date.available | 2014-09-19T08:42:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Chemical Communications, 2013, v. 49 n. 80, p. 9134-9136 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/202606 | - |
dc.description.abstract | The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (logK = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter. © 2013 The Royal Society of Chemistry. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp | - |
dc.relation.ispartof | Chemical Communications | - |
dc.title | Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1 | - |
dc.type | Article | - |
dc.identifier.email | Du, X: xbdu@hku.hk | - |
dc.identifier.email | Li, H: hylichem@hku.hk | - |
dc.identifier.email | Wang, X: wmouse@hku.hk | - |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Sun, H=rp00777 | - |
dc.identifier.doi | 10.1039/c3cc45360j | - |
dc.identifier.pmid | 23962988 | - |
dc.identifier.scopus | eid_2-s2.0-84884193708 | - |
dc.identifier.hkuros | 239330 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 80 | - |
dc.identifier.spage | 9134 | - |
dc.identifier.epage | 9136 | - |
dc.identifier.isi | WOS:000324490200018 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1359-7345 | - |