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Conference Paper: Endothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged mice
Title | Endothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged mice |
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Authors | |
Keywords | Biology |
Issue Date | 2014 |
Publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ |
Citation | The 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. 1 suppl., abstract no. LB655 How to Cite? |
Abstract | Endothelin-1 (ET-1) is a 21 amino acid vasoconstrictor and implicated in the regulation of hypertention. Recently, our colleagues found that transgenic mice (TET-1) with endothelial ET-1 over-expression developed hypertention in young mice by changing vascular properties. However, the effects of over-expressing endothelial ET-1 on cardiovascular system in aged mice are still unclear. Therefore, this study investigated the blood pressure and heart rate of TET-1 aged mice and non-transgenic (NTg) aged mice (1.5-2 years old). A non-invasive tail cuff measurement showed that a significant elevation of both systolic (115.1 ± 2.935 vs 103.5 ± 1.846 mmHg, p<0.01) and diastolic ... |
Description | Abstract no. LB655 This journal suppl. is proceedings of EB 2014 Meeting Open Access Journal |
Persistent Identifier | http://hdl.handle.net/10722/202295 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.412 |
DC Field | Value | Language |
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dc.contributor.author | Luo, X | - |
dc.contributor.author | Xia, Z | - |
dc.contributor.author | Chung, SK | - |
dc.contributor.author | Cheung, CW | - |
dc.date.accessioned | 2014-09-04T07:15:41Z | - |
dc.date.available | 2014-09-04T07:15:41Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 Annual Meeting of Experimental Biology (EB 2014), San Diego, CA., 26-30 April 2014. In The FASEB Journal, 2014, v. 28 n. 1 suppl., abstract no. LB655 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10722/202295 | - |
dc.description | Abstract no. LB655 | - |
dc.description | This journal suppl. is proceedings of EB 2014 Meeting | - |
dc.description | Open Access Journal | - |
dc.description.abstract | Endothelin-1 (ET-1) is a 21 amino acid vasoconstrictor and implicated in the regulation of hypertention. Recently, our colleagues found that transgenic mice (TET-1) with endothelial ET-1 over-expression developed hypertention in young mice by changing vascular properties. However, the effects of over-expressing endothelial ET-1 on cardiovascular system in aged mice are still unclear. Therefore, this study investigated the blood pressure and heart rate of TET-1 aged mice and non-transgenic (NTg) aged mice (1.5-2 years old). A non-invasive tail cuff measurement showed that a significant elevation of both systolic (115.1 ± 2.935 vs 103.5 ± 1.846 mmHg, p<0.01) and diastolic ... | - |
dc.language | eng | - |
dc.publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ | - |
dc.relation.ispartof | The FASEB Journal | - |
dc.subject | Biology | - |
dc.title | Endothelial cell-targeted over-expressing ET-1 leads to increased blood pressure and decreased heart rate in aged mice | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Xia, Z: zyxia@hkucc.hku.hk | - |
dc.identifier.email | Chung, SK: skchung@hkucc.hku.hk | - |
dc.identifier.email | Cheung, CW: cheucw@hku.hk | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 235868 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 1 suppl. | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0892-6638 | - |