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- Publisher Website: 10.4093/dmj.2014.38.5.321
- Scopus: eid_2-s2.0-84908889513
- PMID: 25349818
- WOS: WOS:000219174100001
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Article: Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.
Title | Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. |
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Authors | |
Keywords | Biotin Dietary restriction Lifespan NAD Nicotinamide Sirtuins |
Issue Date | 2014 |
Publisher | Korean Diabetes Association. The Journal's web site is located at http://e-dmj.org/ |
Citation | Diabetes & Metabolism Journal, 2014, v. 38 n. 5, p. 321-329 How to Cite? |
Abstract | Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with the ageing process, i.e., promotion of healthy ageing. Calorie restriction is the only nongenetic and the most robust approach to slow the process of ageing in evolutionarily divergent species, ranging from yeasts, worms, and flies to mammals. Although it has been known for more than 80 years that calorie restriction increases lifespan, a mechanistic understanding of this phenomenon remains elusive. Yeast silent information regulator 2 (Sir2), the founding member of the sirtuin family of protein deacetylases, and its mammalian homologue Sir2-like protein 1 (SIRT1), have been suggested to promote survival and longevity of organisms. SIRT1 exerts protective effects against a number of age-associated disorders. Caloric restriction increases both Sir2 and SIRT1 activity. This review focuses on the mechanistic insights between caloric restriction and Sir2/SIRT1 activation. A number of molecular links, including nicotinamide adenine dinucleotide, nicotinamide, biotin, and related metabolites, are suggested to be the most important conduits mediating caloric restriction-induced Sir2/SIRT1 activation and lifespan extension. |
Persistent Identifier | http://hdl.handle.net/10722/200776 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 1.652 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Y | en_US |
dc.date.accessioned | 2014-08-21T07:01:00Z | - |
dc.date.available | 2014-08-21T07:01:00Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Diabetes & Metabolism Journal, 2014, v. 38 n. 5, p. 321-329 | en_US |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200776 | - |
dc.description.abstract | Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with the ageing process, i.e., promotion of healthy ageing. Calorie restriction is the only nongenetic and the most robust approach to slow the process of ageing in evolutionarily divergent species, ranging from yeasts, worms, and flies to mammals. Although it has been known for more than 80 years that calorie restriction increases lifespan, a mechanistic understanding of this phenomenon remains elusive. Yeast silent information regulator 2 (Sir2), the founding member of the sirtuin family of protein deacetylases, and its mammalian homologue Sir2-like protein 1 (SIRT1), have been suggested to promote survival and longevity of organisms. SIRT1 exerts protective effects against a number of age-associated disorders. Caloric restriction increases both Sir2 and SIRT1 activity. This review focuses on the mechanistic insights between caloric restriction and Sir2/SIRT1 activation. A number of molecular links, including nicotinamide adenine dinucleotide, nicotinamide, biotin, and related metabolites, are suggested to be the most important conduits mediating caloric restriction-induced Sir2/SIRT1 activation and lifespan extension. | - |
dc.language | eng | en_US |
dc.publisher | Korean Diabetes Association. The Journal's web site is located at http://e-dmj.org/ | - |
dc.relation.ispartof | Diabetes & Metabolism Journal | en_US |
dc.subject | Biotin | - |
dc.subject | Dietary restriction | - |
dc.subject | Lifespan | - |
dc.subject | NAD | - |
dc.subject | Nicotinamide | - |
dc.subject | Sirtuins | - |
dc.title | Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wang, Y: yuwanghk@hku.hk | en_US |
dc.identifier.authority | Wang, Y=rp00239 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.4093/dmj.2014.38.5.321 | - |
dc.identifier.pmid | 25349818 | - |
dc.identifier.pmcid | PMC4209345 | - |
dc.identifier.scopus | eid_2-s2.0-84908889513 | - |
dc.identifier.hkuros | 232282 | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 321 | - |
dc.identifier.epage | 329 | - |
dc.identifier.isi | WOS:000219174100001 | - |
dc.publisher.place | Republic of Korea | - |
dc.identifier.issnl | 2233-6079 | - |