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- Publisher Website: 10.1111/j.1600-0714.2012.01171.x
- Scopus: eid_2-s2.0-84865539155
- PMID: 22712799
- WOS: WOS:000307959000008
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Article: High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma
Title | High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma |
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Authors | |
Keywords | Adenoid cystic carcinoma Prognosis Metastasis Death-associated protein kinase-1 Beclin-1 Autophagy Ultraviolet radiation resistance-associated gene Pten |
Issue Date | 2012 |
Citation | Journal of Oral Pathology and Medicine, 2012, v. 41, n. 8, p. 621-629 How to Cite? |
Abstract | Background: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance-associated gene, and phosphatase and tensin homolog in salivary gland ACC samples. Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples. The relationship of their expression with clinicopathological features was analyzed. Results: The data showed significantly lower expression of these genes in the tumor samples than in normal salivary gland tissue samples. Furthermore, Beclin-1 expression was significantly correlated with histological pattern of ACC (P<0.05), and high expression of ultraviolet radiation resistance-associated gene was associated with distant metastasis (P<0.05). Most importantly, univariate and multivariate survival analyses suggested that Beclin-1 protein and mRNA expression in cancer cells were independent prognostic indicators for ACC. Conclusion: Our results suggest that autophagy-regulating genes may participate in the pathogenesis of salivary gland ACC. Further research will be required to gain a better understanding of autophagy in ACC. © 2012 John Wiley & Sons A/S. |
Persistent Identifier | http://hdl.handle.net/10722/200124 |
ISSN | 2021 Impact Factor: 3.539 2020 SCImago Journal Rankings: 0.887 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liang, Lizhong | - |
dc.contributor.author | Ma, Ben | - |
dc.contributor.author | Liang, Yujie | - |
dc.contributor.author | Liu, Haichao | - |
dc.contributor.author | Zheng, Guangsen | - |
dc.contributor.author | Zhang, Tonghan | - |
dc.contributor.author | Chu, Mei | - |
dc.contributor.author | Xu, Pingping | - |
dc.contributor.author | Su, Yuxiong | - |
dc.contributor.author | Liao, Guiqing | - |
dc.date.accessioned | 2014-07-26T23:11:10Z | - |
dc.date.available | 2014-07-26T23:11:10Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Oral Pathology and Medicine, 2012, v. 41, n. 8, p. 621-629 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200124 | - |
dc.description.abstract | Background: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance-associated gene, and phosphatase and tensin homolog in salivary gland ACC samples. Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples. The relationship of their expression with clinicopathological features was analyzed. Results: The data showed significantly lower expression of these genes in the tumor samples than in normal salivary gland tissue samples. Furthermore, Beclin-1 expression was significantly correlated with histological pattern of ACC (P<0.05), and high expression of ultraviolet radiation resistance-associated gene was associated with distant metastasis (P<0.05). Most importantly, univariate and multivariate survival analyses suggested that Beclin-1 protein and mRNA expression in cancer cells were independent prognostic indicators for ACC. Conclusion: Our results suggest that autophagy-regulating genes may participate in the pathogenesis of salivary gland ACC. Further research will be required to gain a better understanding of autophagy in ACC. © 2012 John Wiley & Sons A/S. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Oral Pathology and Medicine | - |
dc.subject | Adenoid cystic carcinoma | - |
dc.subject | Prognosis | - |
dc.subject | Metastasis | - |
dc.subject | Death-associated protein kinase-1 | - |
dc.subject | Beclin-1 | - |
dc.subject | Autophagy | - |
dc.subject | Ultraviolet radiation resistance-associated gene | - |
dc.subject | Pten | - |
dc.title | High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-0714.2012.01171.x | - |
dc.identifier.pmid | 22712799 | - |
dc.identifier.scopus | eid_2-s2.0-84865539155 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 621 | - |
dc.identifier.epage | 629 | - |
dc.identifier.eissn | 1600-0714 | - |
dc.identifier.isi | WOS:000307959000008 | - |
dc.identifier.issnl | 0904-2512 | - |