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- Publisher Website: 10.1177/096120339500400411
- Scopus: eid_2-s2.0-0029075947
- PMID: 8528227
- WOS: WOS:A1995RR88700011
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Article: Dual inhibitory and stimulatory activities in serum from SLE patients and lupus mice that regulate the proliferation of an IL-2-dependent T cell line
Title | Dual inhibitory and stimulatory activities in serum from SLE patients and lupus mice that regulate the proliferation of an IL-2-dependent T cell line |
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Authors | |
Keywords | Inhibitory factor IL-2 CTLL Stimulatory factor |
Issue Date | 1995 |
Citation | Lupus, 1995, v. 4, n. 4, p. 297-303 How to Cite? |
Abstract | In serum and plasma from SLE patients, we have detected elevated levels of factors which regulate proliferative responses of CTLL cells to IL-2. Serum samples containing these factors have dose-dependent dual inhibitory and stimulatory activities on the proliferation of this IL-2-dependent T lymphocyte cell line. At high concentrations, the serum factors inhibit the proliferative responses of CTLL cells to IL-2. At low concentrations, they synergise with IL-2 stimulating the growth of cells. Similar inhibitory activity, but with lower titre, was also found to be elevated in sera of some MRL/lpr mice, an animal model of SLE. Functional characterisation of the serum factors shows that: (1) the inhibitory activity cannot be neutralised by exogenous IL-2; (2) the stimulatory activity is not due to the presence of serum IL-2 but synergy of the factor with IL-2; (3) the factors bind directly to CTLL cells but they do not bind to protein A; and (4) the serum factors are not dialysable but heat labile. The possible pathological implications of the serum factors, particularly for the defective T cell functions in lupus disease, are discussed. |
Persistent Identifier | http://hdl.handle.net/10722/200049 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.812 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, Fangping | - |
dc.contributor.author | Stott, David Ian | - |
dc.date.accessioned | 2014-07-26T23:11:04Z | - |
dc.date.available | 2014-07-26T23:11:04Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Lupus, 1995, v. 4, n. 4, p. 297-303 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200049 | - |
dc.description.abstract | In serum and plasma from SLE patients, we have detected elevated levels of factors which regulate proliferative responses of CTLL cells to IL-2. Serum samples containing these factors have dose-dependent dual inhibitory and stimulatory activities on the proliferation of this IL-2-dependent T lymphocyte cell line. At high concentrations, the serum factors inhibit the proliferative responses of CTLL cells to IL-2. At low concentrations, they synergise with IL-2 stimulating the growth of cells. Similar inhibitory activity, but with lower titre, was also found to be elevated in sera of some MRL/lpr mice, an animal model of SLE. Functional characterisation of the serum factors shows that: (1) the inhibitory activity cannot be neutralised by exogenous IL-2; (2) the stimulatory activity is not due to the presence of serum IL-2 but synergy of the factor with IL-2; (3) the factors bind directly to CTLL cells but they do not bind to protein A; and (4) the serum factors are not dialysable but heat labile. The possible pathological implications of the serum factors, particularly for the defective T cell functions in lupus disease, are discussed. | - |
dc.language | eng | - |
dc.relation.ispartof | Lupus | - |
dc.subject | Inhibitory factor | - |
dc.subject | IL-2 | - |
dc.subject | CTLL | - |
dc.subject | Stimulatory factor | - |
dc.title | Dual inhibitory and stimulatory activities in serum from SLE patients and lupus mice that regulate the proliferation of an IL-2-dependent T cell line | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1177/096120339500400411 | - |
dc.identifier.pmid | 8528227 | - |
dc.identifier.scopus | eid_2-s2.0-0029075947 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 297 | - |
dc.identifier.epage | 303 | - |
dc.identifier.eissn | 1477-0962 | - |
dc.identifier.isi | WOS:A1995RR88700011 | - |
dc.identifier.issnl | 0961-2033 | - |