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Article: The clinicopathological significance of miR-133a in colorectal cancer

TitleThe clinicopathological significance of miR-133a in colorectal cancer
Authors
Issue Date2014
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/dm/
Citation
Disease Markers, 2014, v. 2014, article no. 919283 How to Cite?
AbstractThis study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient's clinicopathological data by statistical analysis. Endogenous expression levels of several potential target genes were determined by qRT-PCR and correlated using Pearson's method. MiR-133a was downregulated in 83.2% of tumors compared to normal mucosal tissue. Higher miR-133a expression in tumor tissues was associated with development of distant metastasis, advanced Dukes and TNM staging, and poor survival. The unfavorable prognosis of higher miR-133a expression was accompanied by dysregulation of potential miR-133a target genes, LIM and SH3 domain protein 1 (LASP1), Caveolin-1 (CAV1), and Fascin-1 (FSCN1). LASP1 was found to possess a negative correlation (γ=-0.23), whereas CAV1 exhibited a significant positive correlation (γ=0.27), and a stronger correlation was found in patients who developed distant metastases (γ=0.42). In addition, a negative correlation of FSCN1 was only found in nonmetastatic patients. In conclusion, miR-133a was downregulated in CRC tissues, but its higher expression correlated with adverse clinical characteristics and poor prognosis. © 2014 Timothy Ming-Hun Wan et al.
Persistent Identifierhttp://hdl.handle.net/10722/199254
ISSN
2021 Impact Factor: 3.464
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, TMHen_US
dc.contributor.authorLam, CSCen_US
dc.contributor.authorNg, Len_US
dc.contributor.authorChow, KMen_US
dc.contributor.authorWong, SKMen_US
dc.contributor.authorLi, HSen_US
dc.contributor.authorMan, HWen_US
dc.contributor.authorLo, OSHen_US
dc.contributor.authorFoo, CCen_US
dc.contributor.authorCheung, Aen_US
dc.contributor.authorYau, TCCen_US
dc.contributor.authorPoon, TCJen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorLaw, WLen_US
dc.contributor.authorPang, RWCen_US
dc.date.accessioned2014-07-22T01:10:17Z-
dc.date.available2014-07-22T01:10:17Z-
dc.date.issued2014en_US
dc.identifier.citationDisease Markers, 2014, v. 2014, article no. 919283en_US
dc.identifier.issn0278-0240-
dc.identifier.urihttp://hdl.handle.net/10722/199254-
dc.description.abstractThis study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient's clinicopathological data by statistical analysis. Endogenous expression levels of several potential target genes were determined by qRT-PCR and correlated using Pearson's method. MiR-133a was downregulated in 83.2% of tumors compared to normal mucosal tissue. Higher miR-133a expression in tumor tissues was associated with development of distant metastasis, advanced Dukes and TNM staging, and poor survival. The unfavorable prognosis of higher miR-133a expression was accompanied by dysregulation of potential miR-133a target genes, LIM and SH3 domain protein 1 (LASP1), Caveolin-1 (CAV1), and Fascin-1 (FSCN1). LASP1 was found to possess a negative correlation (γ=-0.23), whereas CAV1 exhibited a significant positive correlation (γ=0.27), and a stronger correlation was found in patients who developed distant metastases (γ=0.42). In addition, a negative correlation of FSCN1 was only found in nonmetastatic patients. In conclusion, miR-133a was downregulated in CRC tissues, but its higher expression correlated with adverse clinical characteristics and poor prognosis. © 2014 Timothy Ming-Hun Wan et al.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/dm/-
dc.relation.ispartofDisease Markersen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleThe clinicopathological significance of miR-133a in colorectal canceren_US
dc.typeArticleen_US
dc.identifier.emailWan, TMH: tmhwan@hku.hken_US
dc.identifier.emailLam, CSC: colin88@hku.hken_US
dc.identifier.emailNg, L: luing@hku.hken_US
dc.identifier.emailChow, KM: chowakm@hku.hken_US
dc.identifier.emailLi, HS: lhsing@hku.hken_US
dc.identifier.emailMan, HW: johnnyb@hku.hken_US
dc.identifier.emailLo, OSH: oswens@hku.hken_US
dc.identifier.emailFoo, CC: ccfoo@hku.hken_US
dc.identifier.emailYau, TCC: tyaucc@hku.hken_US
dc.identifier.emailPoon, TCJ: tcjensen@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_US
dc.identifier.emailPang, RWC: robertap@hku.hken_US
dc.identifier.authorityFoo, CC=rp01899en_US
dc.identifier.authorityYau, TCC=rp01466en_US
dc.identifier.authorityPoon, TCJ=rp01603en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityLaw, WL=rp00436en_US
dc.identifier.authorityPang, RWC=rp00274en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2014/919283-
dc.identifier.pmid25104873-
dc.identifier.pmcidPMC4101241-
dc.identifier.scopuseid_2-s2.0-84904647875-
dc.identifier.hkuros231683en_US
dc.identifier.volume2014, Article ID 919283en_US
dc.identifier.isiWOS:000338428300001-
dc.identifier.issnl0278-0240-

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