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Article: Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

TitleProductive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response
Authors
KeywordsMERS-CoV
SARS-CoV
Viral replication
Pathogenesis
Cytokine and chemokine response
Antigen-presentation
Issue Date2014
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2014, v. 454-455, p. 197-205 How to Cite?
AbstractThe Middle East respiratory syndrome coronavirus (MERS-CoV) closely resembled severe acute respiratory syndrome coronavirus (SARS-CoV) in disease manifestation as rapidly progressive acute pneumonia with multi-organ dysfunction. Using monocyte-derived-dendritic cells (Mo-DCs), we discovered fundamental discrepancies in the outcome of MERS‐CoV‐ and SARS-CoV-infection. First, MERS-CoV productively infected Mo-DCs while SARS-CoV-infection was abortive. Second, MERS-CoV induced significantly higher levels of IFN-γ, IP-10, IL-12, and RANTES expression than SARS-CoV. Third, MERS-CoV-infection induced higher surface expression of MHC class II (HLA-DR) and the co-stimulatory molecule CD86 than SARS-CoV-infection. Overall, our data suggests that the dendritic cell can serve as an important target of viral replication and a vehicle for dissemination. MERS-CoV-infection in DCs results in the production of a rich combination of cytokines and chemokines, and modulates innate immune response differently from that of SARS-CoV-infection. Our findings may help to explain the apparent discrepancy in the pathogenicity between MERS-CoV and SARS-CoV.
Persistent Identifierhttp://hdl.handle.net/10722/199184
ISSN
2020 Impact Factor: 3.616
2020 SCImago Journal Rankings: 1.389
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, H-
dc.contributor.authorZhou, J-
dc.contributor.authorWong, BHY-
dc.contributor.authorLi, C-
dc.contributor.authorCheng, Z-
dc.contributor.authorLin, X-
dc.contributor.authorPoon, VKM-
dc.contributor.authorSun, T-
dc.contributor.authorLau, CCY-
dc.contributor.authorChan, JFW-
dc.contributor.authorTo, KKW-
dc.contributor.authorChan, KH-
dc.contributor.authorLu, L-
dc.contributor.authorZheng, B-
dc.contributor.authorYuen, KY-
dc.date.accessioned2014-07-22T01:06:18Z-
dc.date.available2014-07-22T01:06:18Z-
dc.date.issued2014-
dc.identifier.citationVirology, 2014, v. 454-455, p. 197-205-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/199184-
dc.description.abstractThe Middle East respiratory syndrome coronavirus (MERS-CoV) closely resembled severe acute respiratory syndrome coronavirus (SARS-CoV) in disease manifestation as rapidly progressive acute pneumonia with multi-organ dysfunction. Using monocyte-derived-dendritic cells (Mo-DCs), we discovered fundamental discrepancies in the outcome of MERS‐CoV‐ and SARS-CoV-infection. First, MERS-CoV productively infected Mo-DCs while SARS-CoV-infection was abortive. Second, MERS-CoV induced significantly higher levels of IFN-γ, IP-10, IL-12, and RANTES expression than SARS-CoV. Third, MERS-CoV-infection induced higher surface expression of MHC class II (HLA-DR) and the co-stimulatory molecule CD86 than SARS-CoV-infection. Overall, our data suggests that the dendritic cell can serve as an important target of viral replication and a vehicle for dissemination. MERS-CoV-infection in DCs results in the production of a rich combination of cytokines and chemokines, and modulates innate immune response differently from that of SARS-CoV-infection. Our findings may help to explain the apparent discrepancy in the pathogenicity between MERS-CoV and SARS-CoV.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro-
dc.relation.ispartofVirology-
dc.subjectMERS-CoV-
dc.subjectSARS-CoV-
dc.subjectViral replication-
dc.subjectPathogenesis-
dc.subjectCytokine and chemokine response-
dc.subjectAntigen-presentation-
dc.titleProductive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response-
dc.typeArticle-
dc.identifier.emailChu, H: hinchu@hku.hk-
dc.identifier.emailZhou, J: jiezhou@hku.hk-
dc.identifier.emailWong, BHY: boscowg@hku.hk-
dc.identifier.emailLi, C: licun@hku.hk-
dc.identifier.emailCheng, Z: chzhshan@hku.hk-
dc.identifier.emailLin, X: linxiang@hku.hk-
dc.identifier.emailPoon, VKM: vinpoon@hku.hk-
dc.identifier.emailSun, T: sunth@hku.hk-
dc.identifier.emailLau, CCY: candylau@graduate.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityChu, H=rp02125-
dc.identifier.authorityZhou, J=rp01412-
dc.identifier.authorityLi, C=rp02783-
dc.identifier.authorityLin, X=rp02623-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityLu, L=rp00477-
dc.identifier.authorityZheng, B=rp00353-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.virol.2014.02.018-
dc.identifier.pmid24725946-
dc.identifier.pmcidPMC7111975-
dc.identifier.scopuseid_2-s2.0-84895742275-
dc.identifier.hkuros230917-
dc.identifier.volume454-455-
dc.identifier.spage197-
dc.identifier.epage205-
dc.identifier.isiWOS:000334655000021-
dc.publisher.placeUnited States-
dc.identifier.issnl0042-6822-

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