File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-84897359999
- PMID: 24137579
- WOS: WOS:000327921200003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: An evaluation of the predictive value of mid-treatment 18F-FDG-PET/CT scans in pediatric lymphomas and undefined criteria of abnormality in quantitative analysis.
Title | An evaluation of the predictive value of mid-treatment 18F-FDG-PET/CT scans in pediatric lymphomas and undefined criteria of abnormality in quantitative analysis. |
---|---|
Authors | |
Keywords | 18F-FDG PET/CT scans Mid treatment Pediatric lymphomas Predictive value |
Issue Date | 2013 |
Citation | Hellenic journal of nuclear medicine, 2013, v. 16, n. 3, p. 169-174 How to Cite? |
Abstract | Our purpose was to evaluate quantitative mid-treatment fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT scans in predicting the quantitative result of the end of treatment 18F-FDG PET/CT scan. With approval of Emory's Institutional Review Board, data were extracted from 273 existing 18F-FDG PET/CT scans of 143 pediatric patients performed for evaluation of lymphoma. The inclusion criteria were the availability of an initial staging scan (D0) and a mid-treatment scan after 1 to 3 cycles of chemotherapy (D1) and a post-treatment scan (D2). Absolute and relative changed of D1 compared to D0 were measured and their values in predicting D3 values were determined. Analysis was performed on a lesion basis (N=78) in 18 patients with an average of 4.3 lesions per patients. Results showed that the predictive value depended on the value selected as significant for the predictors (D1 SUV and D1 %SUV), and on the limit between negative and positive selected for the predicted value D2 SUV. If the maximum SUV<2.0 in D2 was the limit for negative, the negative predictive value if D1<4 was 0.84%. If positive was defined as D2>3.0, the positive predictive value of D1>4 was 100%. In that way outcome was predictable with absolute certainty in as many as 71% of the lesions with a single limit for D1 and D2. In conclusion, in this limited retrospective study the positive predictive value of the mid-treatment scan, was high for the post-treatment result for patient and lesion response seen on D2. |
Persistent Identifier | http://hdl.handle.net/10722/198776 |
ISSN | 2023 Impact Factor: 0.9 2023 SCImago Journal Rankings: 0.262 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhu, Hongyunjune | - |
dc.contributor.author | Halkar, Raghuveer K. | - |
dc.contributor.author | Alavi, Abass A. | - |
dc.contributor.author | Goris, Michael L. | - |
dc.date.accessioned | 2014-07-09T03:42:14Z | - |
dc.date.available | 2014-07-09T03:42:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Hellenic journal of nuclear medicine, 2013, v. 16, n. 3, p. 169-174 | - |
dc.identifier.issn | 1790-5427 | - |
dc.identifier.uri | http://hdl.handle.net/10722/198776 | - |
dc.description.abstract | Our purpose was to evaluate quantitative mid-treatment fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT scans in predicting the quantitative result of the end of treatment 18F-FDG PET/CT scan. With approval of Emory's Institutional Review Board, data were extracted from 273 existing 18F-FDG PET/CT scans of 143 pediatric patients performed for evaluation of lymphoma. The inclusion criteria were the availability of an initial staging scan (D0) and a mid-treatment scan after 1 to 3 cycles of chemotherapy (D1) and a post-treatment scan (D2). Absolute and relative changed of D1 compared to D0 were measured and their values in predicting D3 values were determined. Analysis was performed on a lesion basis (N=78) in 18 patients with an average of 4.3 lesions per patients. Results showed that the predictive value depended on the value selected as significant for the predictors (D1 SUV and D1 %SUV), and on the limit between negative and positive selected for the predicted value D2 SUV. If the maximum SUV<2.0 in D2 was the limit for negative, the negative predictive value if D1<4 was 0.84%. If positive was defined as D2>3.0, the positive predictive value of D1>4 was 100%. In that way outcome was predictable with absolute certainty in as many as 71% of the lesions with a single limit for D1 and D2. In conclusion, in this limited retrospective study the positive predictive value of the mid-treatment scan, was high for the post-treatment result for patient and lesion response seen on D2. | - |
dc.language | eng | - |
dc.relation.ispartof | Hellenic journal of nuclear medicine | - |
dc.subject | 18F-FDG PET/CT scans | - |
dc.subject | Mid treatment | - |
dc.subject | Pediatric lymphomas | - |
dc.subject | Predictive value | - |
dc.title | An evaluation of the predictive value of mid-treatment 18F-FDG-PET/CT scans in pediatric lymphomas and undefined criteria of abnormality in quantitative analysis. | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 24137579 | - |
dc.identifier.scopus | eid_2-s2.0-84897359999 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 169 | - |
dc.identifier.epage | 174 | - |
dc.identifier.isi | WOS:000327921200003 | - |
dc.identifier.issnl | 1790-5427 | - |