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Conference Paper: Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wound
Title | Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wound |
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Authors | |
Issue Date | 2014 |
Citation | The 47th Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014), Banff, AB., Canada, 25-29 May 2014. How to Cite? |
Abstract | BACKGROUND/PURPOSE: Our previous studies revealed that silver nanoparticles (AgNPs) promoted wound healing in part through their anti-inflammatory actions. As recent reports also suggested anti-inflammatory effects of dendrimers, we therefore undertook this study using dendrimers as the delivery system for AgNP to explore any potential synergistic anti-inflammatory efficacy. METHODS: Lipopolysaccharide (LPS) was added to cultured RAW264.7 and J774.1 cells to mimic in vitro inflammation condition, followed by the addition of either silver dendrimer nanocomposite (Ag-DNC), AgNPs or derdrimer. The levels of inflammatory markers TNF-alpha and interleukin-6 were assessed using ELISA assay. Furthermore, in vivo effects such of Ag-DNC, AgNPs or dendrimer were studied in a burn wound model in mice. RESULTS: Our results confirmed that although both naked dendrimer and AgNPs had anti-inflammatory properties, Ag-DNC was shown to have the best anti-inflammatory efficacy than AgNPs or dendrimer alone in in-vitro studies. In-vivo experiments also indicated that animals in the Ag-DNC group had the fastest healing time with the least inflammation. CONCLUSIONS: Our study would suggest that dendrimer could provide additional anti-inflammatory benefits and might be an excellent delivery system for silver nanoparticles for future clinical application. |
Description | Oral Presentations - Basic Science (BS): no. BS13 |
Persistent Identifier | http://hdl.handle.net/10722/198208 |
DC Field | Value | Language |
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dc.contributor.author | Liu, X | en_US |
dc.contributor.author | Lok, CN | en_US |
dc.contributor.author | Zhang, R | en_US |
dc.contributor.author | Wong, KKY | en_US |
dc.date.accessioned | 2014-06-25T02:54:47Z | - |
dc.date.available | 2014-06-25T02:54:47Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 47th Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014), Banff, AB., Canada, 25-29 May 2014. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/198208 | - |
dc.description | Oral Presentations - Basic Science (BS): no. BS13 | - |
dc.description.abstract | BACKGROUND/PURPOSE: Our previous studies revealed that silver nanoparticles (AgNPs) promoted wound healing in part through their anti-inflammatory actions. As recent reports also suggested anti-inflammatory effects of dendrimers, we therefore undertook this study using dendrimers as the delivery system for AgNP to explore any potential synergistic anti-inflammatory efficacy. METHODS: Lipopolysaccharide (LPS) was added to cultured RAW264.7 and J774.1 cells to mimic in vitro inflammation condition, followed by the addition of either silver dendrimer nanocomposite (Ag-DNC), AgNPs or derdrimer. The levels of inflammatory markers TNF-alpha and interleukin-6 were assessed using ELISA assay. Furthermore, in vivo effects such of Ag-DNC, AgNPs or dendrimer were studied in a burn wound model in mice. RESULTS: Our results confirmed that although both naked dendrimer and AgNPs had anti-inflammatory properties, Ag-DNC was shown to have the best anti-inflammatory efficacy than AgNPs or dendrimer alone in in-vitro studies. In-vivo experiments also indicated that animals in the Ag-DNC group had the fastest healing time with the least inflammation. CONCLUSIONS: Our study would suggest that dendrimer could provide additional anti-inflammatory benefits and might be an excellent delivery system for silver nanoparticles for future clinical application. | - |
dc.language | eng | en_US |
dc.relation.ispartof | Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons, PAPS 2014 | en_US |
dc.title | Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles in burn wound | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Liu, X: liuxl@hkucc.hku.hk | en_US |
dc.identifier.email | Wong, KKY: kkywong@hku.hk | en_US |
dc.identifier.authority | Wong, KKY=rp01392 | en_US |
dc.identifier.hkuros | 229591 | en_US |