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Article: Reversible pH lability of cross-linked vault nanocapsules

TitleReversible pH lability of cross-linked vault nanocapsules
Authors
Yu, MNg, BCRome, LHTolbert, SHMonbouquette, HG
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett
Citation
Nano Letters, 2008, v. 8 n. 10, p. 3510-3515 How to Cite?
DOI: http://dx.doi.org/10.1021/nl080536z
AbstractVaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/197918
ISSN
1530-6984
2023 Impact Factor: 9.6
2023 SCImago Journal Rankings: 3.411
PubMed Central ID
PMC3046048
ISI Accession Number ID
WOS:000259906800079

 

DC FieldValueLanguage
dc.contributor.authorYu, M-
dc.contributor.authorNg, BC-
dc.contributor.authorRome, LH-
dc.contributor.authorTolbert, SH-
dc.contributor.authorMonbouquette, HG-
dc.date.accessioned2014-06-11T07:13:04Z-
dc.date.available2014-06-11T07:13:04Z-
dc.date.issued2008-
dc.identifier.citationNano Letters, 2008, v. 8 n. 10, p. 3510-3515-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/197918-
dc.description.abstractVaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner. © 2008 American Chemical Society.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett-
dc.relation.ispartofNano Letters-
dc.subject.meshChemistry, Pharmaceutical - methods-
dc.subject.meshDrug Delivery Systems-
dc.subject.meshNanocapsules - chemistry-
dc.subject.meshNanoparticles - chemistry-
dc.subject.meshNanotechnology - methods-
dc.titleReversible pH lability of cross-linked vault nanocapsulesen_US
dc.typeArticleen_US
dc.identifier.emailNg, BC: ngbenny@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1021/nl080536z-
dc.identifier.pmid18803423-
dc.identifier.pmcidPMC3046048-
dc.identifier.scopuseid_2-s2.0-56149111717-
dc.identifier.hkuros202528-
dc.identifier.volume8-
dc.identifier.issue10-
dc.identifier.spage3510-
dc.identifier.epage3515-
dc.identifier.isiWOS:000259906800079-
dc.publisher.placeUnited States-
dc.identifier.issnl1530-6984-

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