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Conference Paper: Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis

TitleNovel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis
Authors
Ko, FCFYeung, YSMao, XYam, JWP
KeywordsMedical sciences
Oncology
Issue Date2014
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
The 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565 How to Cite?
DOI: http://dx.doi.org/10.1158/1538-7445.AM2014-1565
AbstractHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ...
DescriptionMolecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565
This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ...
Persistent Identifierhttp://hdl.handle.net/10722/197695
ISSN
0008-5472
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
ISI Accession Number ID
WOS:000349906901291

 

DC FieldValueLanguage
dc.contributor.authorKo, FCF-
dc.contributor.authorYeung, YS-
dc.contributor.authorMao, X-
dc.contributor.authorYam, JWP-
dc.date.accessioned2014-05-29T08:42:46Z-
dc.date.available2014-05-29T08:42:46Z-
dc.date.issued2014-
dc.identifier.citationThe 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/197695-
dc.descriptionMolecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565-
dc.descriptionThis journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ...-
dc.description.abstractHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ...-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.subjectMedical sciences-
dc.subjectOncology-
dc.titleNovel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis-
dc.typeConference_Paper-
dc.identifier.emailKo, FCF: bokcf@hku.hk-
dc.identifier.emailYeung, YS: yeungys@hku.hk-
dc.identifier.emailMao, X: susanmao@hku.hk-
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hk-
dc.identifier.authorityYam, JWP=rp00468-
dc.description.natureabstract-
dc.identifier.doi10.1158/1538-7445.AM2014-1565-
dc.identifier.hkuros228911-
dc.identifier.volume74-
dc.identifier.issue19 suppl.-
dc.identifier.isiWOS:000349906901291-
dc.publisher.placeUnited States-
dc.identifier.issnl0008-5472-

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