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Article: Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors

TitleRole of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors
Authors
Lee, MYCheung, CYPeiris, JSM
Issue Date2013
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35 How to Cite?
Abstract1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.
Persistent Identifierhttp://hdl.handle.net/10722/196376
ISSN
1024-2708
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261

 

DC FieldValueLanguage
dc.contributor.authorLee, MYen_US
dc.contributor.authorCheung, CYen_US
dc.contributor.authorPeiris, JSMen_US
dc.date.accessioned2014-04-01T08:52:03Z-
dc.date.available2014-04-01T08:52:03Z-
dc.date.issued2013en_US
dc.identifier.citationHong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/196376-
dc.description.abstract1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.en_US
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRole of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitorsen_US
dc.typeArticleen_US
dc.identifier.emailLee, MY: suki@hku.hken_US
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityLee, MY=rp01536en_US
dc.identifier.authorityCheung, CY=rp00404en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturepublished_or_final_version-
dc.identifier.pmid23775184-
dc.identifier.scopuseid_2-s2.0-84893435117-
dc.identifier.hkuros228438en_US
dc.identifier.hkuros277056-
dc.identifier.volume19en_US
dc.identifier.issueSuppl. 4en_US
dc.identifier.spage29en_US
dc.identifier.epage35en_US
dc.publisher.placeHong Kong-
dc.identifier.issnl1024-2708-

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