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Patent History
- ApplicationPC T/CN2012000891 2012-06-29
- PublicationWO 2013000278 2013-01-03
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published patent: TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE
| Title | TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE |
|---|---|
| Priority Date | 2011-06-30 US 12/1503453P |
| Inventors | |
| Issue Date | 2013 |
| Citation | WO Published patent application WO 2013000278. World Intellectual Property Organization (WIPO), PatentScope, 2013 How to Cite? |
| Abstract | A regulatable gene expression construct comprising a nucleic acid molecule comprising a two- way riboswitch operably linked to a target sequence. Also provided is a library screening strategy for efficient creation of target-specific riboswitches. A theophylline-repressible and IPTG-inducible riboswitch device achieves portable control of gene expression control in a 'two- way' manner. The default state of target genes is ON; the targets are switched off by adding theophylline, and switched back to the ON-state by adding IPTG without changing growth medium. The riboswitch device regulates gene expression in a portabe, adjustable, and two-way manner with a variety of scientific and biotechnological applications. |
| Persistent Identifier | http://hdl.handle.net/10722/195810 |
| References |
| DC Field | Value | Language |
|---|---|---|
| dc.date.accessioned | 2014-03-12T09:14:30Z | - |
| dc.date.available | 2014-03-12T09:14:30Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.citation | WO Published patent application WO 2013000278. World Intellectual Property Organization (WIPO), PatentScope, 2013 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/195810 | - |
| dc.description.abstract | A regulatable gene expression construct comprising a nucleic acid molecule comprising a two- way riboswitch operably linked to a target sequence. Also provided is a library screening strategy for efficient creation of target-specific riboswitches. A theophylline-repressible and IPTG-inducible riboswitch device achieves portable control of gene expression control in a 'two- way' manner. The default state of target genes is ON; the targets are switched off by adding theophylline, and switched back to the ON-state by adding IPTG without changing growth medium. The riboswitch device regulates gene expression in a portabe, adjustable, and two-way manner with a variety of scientific and biotechnological applications. | en_US |
| dc.title | TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE | en_US |
| dc.type | Patent | en_US |
| dc.identifier.authority | HUANG, JIANDONG=rp00451 | en_US |
| dc.description.nature | published_or_final_version | - |
| dc.contributor.inventor | HUANG, JIANDONG | en_US |
| dc.contributor.inventor | JIN, YE | en_US |
| patents.identifier.application | PC T/CN2012000891 | en_US |
| patents.description.assignee | UNIV HONG KONG [CN]; HUANG JIANDONG [CN]; JIN YE [CN] | en_US |
| patents.description.country | World Intellectual Property Organization (WIPO) | en_US |
| patents.date.publication | 2013-01-03 | en_US |
| dc.relation.references | US 2009170793 (A1) 2009-07-02 | en_US |
| dc.relation.references | US 7563601 (B1) 2009-07-21 | en_US |
| patents.identifier.hkutechid | Bioch-2011-00381-2 | - |
| patents.date.application | 2012-06-29 | en_US |
| patents.date.priority | 2011-06-30 US 12/1503453P | en_US |
| patents.description.cc | wo | en_US |
| patents.identifier.publication | WO 2013000278 | en_US |
| patents.relation.family | US 2013004980 (A1) 2013-01-03 | en_US |
| patents.description.kind | A1 | en_US |
| patents.type | Patent_published | en_US |