File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/ana.1127
- Scopus: eid_2-s2.0-0034853875
- PMID: 11558786
- WOS: WOS:000170803200005
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: ANNA-3 anti-neuronal nuclear antibody: Marker of lung cancer-related autoimmunity
Title | ANNA-3 anti-neuronal nuclear antibody: Marker of lung cancer-related autoimmunity |
---|---|
Authors | |
Issue Date | 2001 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645 |
Citation | Annals of Neurology, 2001, v. 50 n. 3, p. 301-311 How to Cite? |
Abstract | Two anti-neuronal nuclear antibodies (ANNA-1 and ANNA-2) are markers of paraneoplastic neurological autoimmunity related to small-cell carcinoma. ANNA-2 is also related to breast carcinoma. Here we define a third IgG specificity (ANNA-3), identified in 11 patients (10 adults) by immunofluorescence screening of sera from approximately 68,000 patients with suspected paraneoplastic neurological syndromes. ANNA-3 binds prominently to nuclei of cerebellar Purkinje neurons, not to cytoplasm, granular neurons, or enteric neurons, but distinctively to renal glomerular podocytes. Western blots revealed an approximately 170 kDa antigen, in cerebellum and small-cell carcinoma. IgG eluted from this protein reproduced Purkinje and podocyte nuclear staining. ANNA-2 in 8 of 32 cases bound to podocyte nuclei but not to the 170 kDa protein. Healthy subjects and control neurological and cancer patients lack ANNA-3. Neurological accompaniments, subacute and usually multifocal, included sensory/sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy. All of 9 adults followed had an intrathoracic neoplasm, seven biopsied within 7 months (five small-cell lung carcinomas and two adenocarcinomas, one lung, one esophagus) and two imaged, one early, the other 3 years later. Thus, immunohistochemical and Western blot criteria can now identify six IgG markers of neurological autoimmunity related to small-cell carcinoma, their frequency being ANNA-1 > collapsin response-mediator protein-5 > amphiphysin > Purkinje cell cytoplasmic antibody-2 = ANNA-2 = ANNA-3. |
Persistent Identifier | http://hdl.handle.net/10722/195544 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 3.600 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Vernino, S | - |
dc.contributor.author | Lennon, VA | - |
dc.date.accessioned | 2014-03-04T01:27:51Z | - |
dc.date.available | 2014-03-04T01:27:51Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Annals of Neurology, 2001, v. 50 n. 3, p. 301-311 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/10722/195544 | - |
dc.description.abstract | Two anti-neuronal nuclear antibodies (ANNA-1 and ANNA-2) are markers of paraneoplastic neurological autoimmunity related to small-cell carcinoma. ANNA-2 is also related to breast carcinoma. Here we define a third IgG specificity (ANNA-3), identified in 11 patients (10 adults) by immunofluorescence screening of sera from approximately 68,000 patients with suspected paraneoplastic neurological syndromes. ANNA-3 binds prominently to nuclei of cerebellar Purkinje neurons, not to cytoplasm, granular neurons, or enteric neurons, but distinctively to renal glomerular podocytes. Western blots revealed an approximately 170 kDa antigen, in cerebellum and small-cell carcinoma. IgG eluted from this protein reproduced Purkinje and podocyte nuclear staining. ANNA-2 in 8 of 32 cases bound to podocyte nuclei but not to the 170 kDa protein. Healthy subjects and control neurological and cancer patients lack ANNA-3. Neurological accompaniments, subacute and usually multifocal, included sensory/sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy. All of 9 adults followed had an intrathoracic neoplasm, seven biopsied within 7 months (five small-cell lung carcinomas and two adenocarcinomas, one lung, one esophagus) and two imaged, one early, the other 3 years later. Thus, immunohistochemical and Western blot criteria can now identify six IgG markers of neurological autoimmunity related to small-cell carcinoma, their frequency being ANNA-1 > collapsin response-mediator protein-5 > amphiphysin > Purkinje cell cytoplasmic antibody-2 = ANNA-2 = ANNA-3. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645 | - |
dc.relation.ispartof | Annals of Neurology | - |
dc.rights | Annals of Neurology. Copyright © John Wiley & Sons, Inc. | - |
dc.rights | Special Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.) | - |
dc.subject.mesh | Antibodies, Antinuclear - blood | - |
dc.subject.mesh | Autoimmunity - immunology | - |
dc.subject.mesh | Carcinoma, Small Cell - blood - immunology | - |
dc.subject.mesh | Lung Neoplasms - blood - immunology | - |
dc.subject.mesh | Paraneoplastic Syndromes, Nervous System - blood - immunology | - |
dc.title | ANNA-3 anti-neuronal nuclear antibody: Marker of lung cancer-related autoimmunity | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, KH: koonho@hkucc.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ana.1127 | - |
dc.identifier.pmid | 11558786 | - |
dc.identifier.scopus | eid_2-s2.0-0034853875 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 301 | - |
dc.identifier.epage | 311 | - |
dc.identifier.isi | WOS:000170803200005 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0364-5134 | - |