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Conference Paper: Diffusional kurtosis imaging detects age-related grey matter changes in the normal mouse brain

TitleDiffusional kurtosis imaging detects age-related grey matter changes in the normal mouse brain
Authors
Falangola, MFGuilfoyle, DHui, SKHu, CGerum, SLaFrancois, JNie, XJensen, JHTabesh, AHelpern, JA
Issue Date2012
Citation
The 20th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. How to Cite?
AbstractSince the transition from young to aged adult during the normal aging process leads to changes in grey matter morphology, characterizing the age-related diffusion patterns in the rodent brain is important for interpreting and differentiating the changes associated with pathological process in rodents’ models of neurodegenerative diseases. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by diffusion tensor imaging. Here we report that the DKI can characterize the age-related microstructural changes in the cortex and sub-cortical regions in the normal mouse brain.
Persistent Identifierhttp://hdl.handle.net/10722/195270

 

DC FieldValueLanguage
dc.contributor.authorFalangola, MFen_US
dc.contributor.authorGuilfoyle, Den_US
dc.contributor.authorHui, SKen_US
dc.contributor.authorHu, Cen_US
dc.contributor.authorGerum, Sen_US
dc.contributor.authorLaFrancois, Jen_US
dc.contributor.authorNie, Xen_US
dc.contributor.authorJensen, JHen_US
dc.contributor.authorTabesh, Aen_US
dc.contributor.authorHelpern, JAen_US
dc.date.accessioned2014-02-26T02:07:49Z-
dc.date.available2014-02-26T02:07:49Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/195270-
dc.description.abstractSince the transition from young to aged adult during the normal aging process leads to changes in grey matter morphology, characterizing the age-related diffusion patterns in the rodent brain is important for interpreting and differentiating the changes associated with pathological process in rodents’ models of neurodegenerative diseases. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by diffusion tensor imaging. Here we report that the DKI can characterize the age-related microstructural changes in the cortex and sub-cortical regions in the normal mouse brain.en_US
dc.languageengen_US
dc.relation.ispartofISMRM 20th Annual Meetingen_US
dc.titleDiffusional kurtosis imaging detects age-related grey matter changes in the normal mouse brainen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, SK: edshui@hku.hken_US
dc.identifier.authorityHui, SK=rp01832en_US

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