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Article: Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells

TitleFull-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells
Authors
Ng, Y-KLau, W-SLui, VWYCheng, AS-LNg, PK-STsui, SK-WCheung, YSLai, PBS
KeywordsAkt
Hep3B
Huh7
NORE1B
PLC/PRF/5
Staurosporine
Stk4
Issue Date2013
Citation
FEBS Letters, 2013, v. 587 n. 5, p. 496-503 How to Cite?
DOI: http://dx.doi.org/10.1016/j.febslet.2013.01.018
AbstractThe putative tumor suppressor Mst1, when cleaved to its 36 kDa cleaved form, amplifies apoptotic signals. We found that Mst1 was predominantly expressed in its full-length form in 76% (17/25 cases) of hepatocellular carcinoma (HCC) tumors. Mst1 cleavage was basically absent in HCC cells. Ectopic full-length Mst1 expression increased the growth of HCC cells by 55-80% within 3 days after transfection. Expression of exogenous NORE1B, a tumor suppressor commonly lost in HCC tumors (∼56% of our cohort), was sufficient to suppress the growth promotion of full-length Mst1. Hence, Mst1 exhibits a growth promoting activity in HCC cells upon NORE1B downregulation. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/194375
ISSN
0014-5793
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.208
ISI Accession Number ID
WOS:000315217900017

 

DC FieldValueLanguage
dc.contributor.authorNg, Y-K-
dc.contributor.authorLau, W-S-
dc.contributor.authorLui, VWY-
dc.contributor.authorCheng, AS-L-
dc.contributor.authorNg, PK-S-
dc.contributor.authorTsui, SK-W-
dc.contributor.authorCheung, YS-
dc.contributor.authorLai, PBS-
dc.date.accessioned2014-01-30T03:32:30Z-
dc.date.available2014-01-30T03:32:30Z-
dc.date.issued2013-
dc.identifier.citationFEBS Letters, 2013, v. 587 n. 5, p. 496-503-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/194375-
dc.description.abstractThe putative tumor suppressor Mst1, when cleaved to its 36 kDa cleaved form, amplifies apoptotic signals. We found that Mst1 was predominantly expressed in its full-length form in 76% (17/25 cases) of hepatocellular carcinoma (HCC) tumors. Mst1 cleavage was basically absent in HCC cells. Ectopic full-length Mst1 expression increased the growth of HCC cells by 55-80% within 3 days after transfection. Expression of exogenous NORE1B, a tumor suppressor commonly lost in HCC tumors (∼56% of our cohort), was sufficient to suppress the growth promotion of full-length Mst1. Hence, Mst1 exhibits a growth promoting activity in HCC cells upon NORE1B downregulation. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofFEBS Letters-
dc.subjectAkt-
dc.subjectHep3B-
dc.subjectHuh7-
dc.subjectNORE1B-
dc.subjectPLC/PRF/5-
dc.subjectStaurosporine-
dc.subjectStk4-
dc.titleFull-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2013.01.018-
dc.identifier.pmid23347832-
dc.identifier.scopuseid_2-s2.0-84874193499-
dc.identifier.volume587-
dc.identifier.issue5-
dc.identifier.spage496-
dc.identifier.epage503-
dc.identifier.isiWOS:000315217900017-
dc.identifier.issnl0014-5793-

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