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Patent History
- ApplicationUS 11/748992 2007-05-15
- GrantedUS 20070212349 2007-09-13
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granted patent: BROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES
Title | BROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES |
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Granted Patent | US 20070212349 |
Granted Date | 2007-09-13 |
Priority Date | 2007-05-15 US 11/748992 2001-10-16 US 09/329709P 2002-10-16 PCT/US2002033165 2004-05-05 US 10/492729 |
Inventors | |
Issue Date | 2007 |
Citation | US Patent US 20070212349. Washington, DC: US Patent and Trademark Office (USPTO), 2007 How to Cite? |
Abstract | The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention. |
Persistent Identifier | http://hdl.handle.net/10722/194058 |
DC Field | Value | Language |
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dc.date.accessioned | 2014-01-29T05:23:45Z | - |
dc.date.available | 2014-01-29T05:23:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | US Patent US 20070212349. Washington, DC: US Patent and Trademark Office (USPTO), 2007 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/194058 | - |
dc.description.abstract | The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention. | en_US |
dc.relation.isreferencedby | WO 2012047598 (A1) 2012-04-12 | en_US |
dc.title | BROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES | en_US |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | - |
dc.contributor.inventor | DIMITROV DIMITER S | en_US |
dc.contributor.inventor | MOULARD MAXIME | en_US |
dc.contributor.inventor | XIAO XIADONG | en_US |
dc.contributor.inventor | SHU YUUEI | en_US |
dc.contributor.inventor | PHOGAT SANJAY K | en_US |
dc.contributor.inventor | ZHANG MEI-YUN | en_US |
dc.contributor.inventor | BURTON DENNIS | en_US |
patents.identifier.application | US 11/748992 | en_US |
patents.identifier.granted | US 20070212349 | en_US |
patents.description.assignee | SCRIPPS RESEARCH INST [US] | en_US |
patents.description.country | United States of America | en_US |
patents.date.granted | 2007-09-13 | en_US |
patents.date.application | 2007-05-15 | en_US |
patents.date.priority | 2007-05-15 US 11/748992 | en_US |
patents.date.priority | 2001-10-16 US 09/329709P | en_US |
patents.date.priority | 2002-10-16 PCT/US2002033165 | en_US |
patents.date.priority | 2004-05-05 US 10/492729 | en_US |
patents.description.cc | us | en_US |
patents.relation.family | AT 481109 (T) 2010-10-15 | en_US |
patents.relation.family | AU 2002337885 (B1) 2003-04-28 | en_US |
patents.relation.family | CA 2463931 (A1) 2003-04-24 | en_US |
patents.relation.family | EP 1450857 (A2) 2004-09-01 | en_US |
patents.relation.family | US 2004259075 (A1) 2004-12-23 | en_US |
patents.relation.family | US 7223844 (B2) 2007-05-29 | en_US |
patents.relation.family | US 7378093 (B2) 2008-05-27 | en_US |
patents.relation.family | WO 03033666 (A2) 2003-04-24 | en_US |
patents.description.kind | A1 | en_US |
patents.type | Patent_granted | en_US |