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Patent History
- ApplicationPC T/US2002029003 2002-09-13
- PublicationWO 03025124 2003-03-27
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published patent: IMMUNOGLOBULIN HAVING PARTICULAR FRAMEWORK SCAFFOLD AND METHODS OF MAKING AND USING
Title | IMMUNOGLOBULIN HAVING PARTICULAR FRAMEWORK SCAFFOLD AND METHODS OF MAKING AND USING |
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Priority Date | 2001-09-14 US 09/318904P |
Inventors | |
Issue Date | 2003 |
Citation | WO Published patent application WO 03025124. World Intellectual Property Organization (WIPO), PatentScope, 2003 How to Cite? |
Abstract | This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention. |
Persistent Identifier | http://hdl.handle.net/10722/194057 |
References |
DC Field | Value | Language |
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dc.date.accessioned | 2014-01-29T05:23:44Z | - |
dc.date.available | 2014-01-29T05:23:44Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | WO Published patent application WO 03025124. World Intellectual Property Organization (WIPO), PatentScope, 2003 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/194057 | - |
dc.description.abstract | This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention. | en_US |
dc.relation.isreferencedby | WO 03054021 (A2) 2003-07-03 | en_US |
dc.relation.isreferencedby | WO 03054021 (A3) 2004-02-12 | en_US |
dc.title | IMMUNOGLOBULIN HAVING PARTICULAR FRAMEWORK SCAFFOLD AND METHODS OF MAKING AND USING | en_US |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | - |
dc.contributor.inventor | ZHANG, MEI YUN | en_US |
dc.contributor.inventor | SCHILLBERG, STEFAN | en_US |
dc.contributor.inventor | ZIMMERMANN, SABINE | en_US |
dc.contributor.inventor | DI FIORE, STEFANO | en_US |
dc.contributor.inventor | EMANS, NEIL | en_US |
dc.contributor.inventor | FISCHER, RAINER | en_US |
patents.identifier.application | PC T/US2002029003 | en_US |
patents.description.assignee | FRAUNHOFER INST MOLEKULARBIOLO [DE]; ZHANG MEI YUN [US]; SCHILLBERG STEFAN [DE]; ZIMMERMANN SABINE [DE]; DI FIORE STEFANO [DE]; EMANS NEIL [BE]; FISCHER RAINER [DE] | en_US |
patents.description.country | World Intellectual Property Organization (WIPO) | en_US |
patents.date.publication | 2003-03-27 | en_US |
dc.relation.references | WO 9109967 (A1) 1991-07-11 | en_US |
dc.relation.references | XP 001023515 | en_US |
patents.date.application | 2002-09-13 | en_US |
patents.date.priority | 2001-09-14 US 09/318904P | en_US |
patents.description.cc | wo | en_US |
patents.identifier.publication | WO 03025124 | en_US |
patents.relation.family | AU 2002324973 (A1) 2003-04-01 | en_US |
patents.relation.family | EP 1434800 (A2) 2004-07-07 | en_US |
patents.relation.family | US 2005037420 (A1) 2005-02-17 | en_US |
patents.description.kind | A2 | en_US |
patents.type | Patent_published | en_US |