Outcome of local Chinese men undergoing primary androgen deprivation therapy for prostate cancer

Abstract

Objective: To evaluate and analyze the outcome of patients with prostate cancer treated with primary androgen deprivation therapy.

Patients & Method: Patients with prostate cancer treated with primary androgen deprivation therapy in Queen Mary Hospital from 2001 to 2011 were reviewed. Survival outcome and predictive factors of survival were evaluated with Kaplan-Meier and Cox regression analyses.

Results: A total of 281 patients were included with a mean follow up of 31.5 ± 23.4 months. The 5-year overall and cancer-specific survival rates were 41% and 65% respectively. Gleason score, presence of bone metastases, clinical stage, baseline PSA, PSA nadir and time to PSA nadir were significant predictor factors of overall and cancer-specific survival upon Kaplan-Meier analysis. PSA nadir (p < 0.001, 95% CI 1.007–1.019) and time to PSA nadir (p = 0.007, 95% CI 0.886–0.981) were the only two significant predictive factors of cancer-specific survival upon Cox regression analysis. For patients of any PSA nadir subgroup, time to PSA nadir remained as a significant predictor of both overall and cancer-specific survival.

Conclusion: In local Chinese men with advanced or metastatic prostate cancer receiving primary androgen deprivation therapy, their PSA nadir and time to PSA nadir were significant factors affecting cancer-specific survival upon multivariate analysis.