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Conference Paper: Variability in the immunogenicity of inactivated seasonal influenza vaccine in children due to age and recent previous influenza vaccination
Title | Variability in the immunogenicity of inactivated seasonal influenza vaccine in children due to age and recent previous influenza vaccination |
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Authors | |
Issue Date | 2013 |
Publisher | International Society for Influenza and other Respiratory Virus Diseases (ISIRV). |
Citation | The 8th International Scientific Conference of Options for the Control of Influenza (Options-8), Cape Town, South Africa, 5-10 September 2013. In Conference Abstracts, 2013, p. 387, abstract no. P2-529 How to Cite? |
Abstract | Background: Annual receipt of trivalent inactivated influenza (TIV) vaccination is recommended for
school-age children in some countries. However, there is little data on the variability of the
immunogenicity of influenza vaccination in children and how this is affected by their age and recent
influenza vaccination history. Materials and Methods: We used data on children in a Hong Kong
community-based study who were randomized to receive TIV before the 2009-2010 influenza season.
Antibody titers against seasonal and pandemic A(H1N1), seasonal A(H3N2), and two B influenza
viruses (B/Brisbane and B/Florida) were measured by hemagglutination inhibition immediately before
and 1 month after vaccination (Cowling et al. Clin Infect Dis. 2012). Multivariate regression models
were fitted in a Bayesian framework to characterize the distribution of changes in antibody titers
following vaccination and update previous findings by considering the correlation between virus
strains (Ng et al. Pediatr Infect Dis J. 2013). Results: In 452 subjects, statistically significant rises in
the geometric means of all antibody titers were observed, with those against the virus strains included
in the TIV rising by geometric means of 7.95 to 13.36; those against pandemic A(H1N1) and B/Florida
rose by 1.47 and 4.21, respectively. Geometric standard deviations were between 3.76 and 8.41
around the geometric means, with pandemic A(H1N1) showing the least variability in rises. The most
closely correlated titer increases were those for the two influenza B viruses, while increases in
pandemic A(H1N1) titers were unrelated to any other titer. Being vaccinated in either of the two
previous years significantly reduced the increase in seasonal A(H1N1) and A(H3N2) antibody titers,
while among children not vaccinated in the previous 2 years, those aged > 9 years experienced
significantly higher increases in the influenza B titers than those aged 6-8 years. Conclusions:
Increases in antibody titers following vaccination can vary depending on age and vaccination history.
Results from our study suggest that humoral antibody response to TIV may be lower in children
receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. |
Description | Poster Session: Vaccines |
Persistent Identifier | http://hdl.handle.net/10722/191988 |
DC Field | Value | Language |
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dc.contributor.author | Freeman, G | en_US |
dc.contributor.author | Perera, RAPM | en_US |
dc.contributor.author | Fang, J | en_US |
dc.contributor.author | Ng, S | en_US |
dc.contributor.author | Ip, DKM | en_US |
dc.contributor.author | Leung, GM | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Cowling, BJ | en_US |
dc.date.accessioned | 2013-10-15T07:45:37Z | - |
dc.date.available | 2013-10-15T07:45:37Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 8th International Scientific Conference of Options for the Control of Influenza (Options-8), Cape Town, South Africa, 5-10 September 2013. In Conference Abstracts, 2013, p. 387, abstract no. P2-529 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/191988 | - |
dc.description | Poster Session: Vaccines | - |
dc.description.abstract | Background: Annual receipt of trivalent inactivated influenza (TIV) vaccination is recommended for school-age children in some countries. However, there is little data on the variability of the immunogenicity of influenza vaccination in children and how this is affected by their age and recent influenza vaccination history. Materials and Methods: We used data on children in a Hong Kong community-based study who were randomized to receive TIV before the 2009-2010 influenza season. Antibody titers against seasonal and pandemic A(H1N1), seasonal A(H3N2), and two B influenza viruses (B/Brisbane and B/Florida) were measured by hemagglutination inhibition immediately before and 1 month after vaccination (Cowling et al. Clin Infect Dis. 2012). Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titers following vaccination and update previous findings by considering the correlation between virus strains (Ng et al. Pediatr Infect Dis J. 2013). Results: In 452 subjects, statistically significant rises in the geometric means of all antibody titers were observed, with those against the virus strains included in the TIV rising by geometric means of 7.95 to 13.36; those against pandemic A(H1N1) and B/Florida rose by 1.47 and 4.21, respectively. Geometric standard deviations were between 3.76 and 8.41 around the geometric means, with pandemic A(H1N1) showing the least variability in rises. The most closely correlated titer increases were those for the two influenza B viruses, while increases in pandemic A(H1N1) titers were unrelated to any other titer. Being vaccinated in either of the two previous years significantly reduced the increase in seasonal A(H1N1) and A(H3N2) antibody titers, while among children not vaccinated in the previous 2 years, those aged > 9 years experienced significantly higher increases in the influenza B titers than those aged 6-8 years. Conclusions: Increases in antibody titers following vaccination can vary depending on age and vaccination history. Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. | - |
dc.language | eng | en_US |
dc.publisher | International Society for Influenza and other Respiratory Virus Diseases (ISIRV). | en_US |
dc.relation.ispartof | ISIRV Options-8 Conference | en_US |
dc.title | Variability in the immunogenicity of inactivated seasonal influenza vaccine in children due to age and recent previous influenza vaccination | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Freeman, G: gfreeman@hku.hk | en_US |
dc.identifier.email | Perera, RAPM: mahenp@hku.hk | en_US |
dc.identifier.email | Fang, J: vickyf@hku.hk | en_US |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | en_US |
dc.identifier.email | Leung, GM: gmleung@hku.hk | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | en_US |
dc.identifier.authority | Freeman, G=rp01694 | en_US |
dc.identifier.authority | Ip, DKM=rp00256 | en_US |
dc.identifier.authority | Leung, GM=rp00460 | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.identifier.authority | Cowling, BJ=rp01326 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 225746 | en_US |
dc.identifier.spage | 387, abstract no. P2-529 | - |
dc.identifier.epage | 387, abstract no. P2-529 | - |
dc.publisher.place | United Kingdom | en_US |