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Conference Paper: Propofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitrite
Title | Propofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitrite |
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Authors | |
Issue Date | 2013 |
Publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ |
Citation | The 2013 Annual Meeting of Experimental Biology (EB 2013), Boston, MA., 28 March-1 April 2013. In The FASEB Journal, 2013, v. 27 n. S1, abstract no. lb619 How to Cite? |
Abstract | Propofol, an aesthetic with antioxidant and peroxynitrite (ONOO–) scavenging property, when given during reperfusion attenuates myocardial ischemia/reperfusion (MI/R) injury. Heme oxygenase-1 (HO-1) and STAT3 are key proteins in postconditioning (PC) cardioprotection. We explored if Propofol PC (PPC) confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. Rats were subjected to 30 min coronary artery occlusion and 120 min reperfusion in vivo. Rats (n=7/group) were respectively treated with Propofol (2mg/kg), IPC, ONOO– generator SIN-1(1.5 mg/kg), ONOO– scavenger FeTPPS (10 mg/kg) during MI/R. Also, primarily cultured cardiomyocytes were subjected to hypoxia/re-oxygenation in the absence or presence of SIN-1 or FeTPPS. PPC conferred similar cardioprotection to IPC in reducing postischemic myocardial infarction compared to control. FeTPPS enhanced PPC cardioprotection while SIN-1 abolished PPC cardioprotection. HO-1 and p-STAT3 protein expression was increased in PPC group compared to control and it was associated with decreased ONOO– production and increased antioxidant capacity. PPC also attenuated post-hypoxic lactate dehydrogenase in vitro. However, HO-1/STAT3 gene knockdown abolished protective effect of PPC. In conclusion, PPC confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. |
Persistent Identifier | http://hdl.handle.net/10722/190357 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mao, X | en_US |
dc.contributor.author | Li, H | en_US |
dc.contributor.author | Irwin, M | en_US |
dc.contributor.author | Wong, G | en_US |
dc.contributor.author | Xia, Z | en_US |
dc.date.accessioned | 2013-09-17T15:20:19Z | - |
dc.date.available | 2013-09-17T15:20:19Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 2013 Annual Meeting of Experimental Biology (EB 2013), Boston, MA., 28 March-1 April 2013. In The FASEB Journal, 2013, v. 27 n. S1, abstract no. lb619 | en_US |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10722/190357 | - |
dc.description.abstract | Propofol, an aesthetic with antioxidant and peroxynitrite (ONOO–) scavenging property, when given during reperfusion attenuates myocardial ischemia/reperfusion (MI/R) injury. Heme oxygenase-1 (HO-1) and STAT3 are key proteins in postconditioning (PC) cardioprotection. We explored if Propofol PC (PPC) confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. Rats were subjected to 30 min coronary artery occlusion and 120 min reperfusion in vivo. Rats (n=7/group) were respectively treated with Propofol (2mg/kg), IPC, ONOO– generator SIN-1(1.5 mg/kg), ONOO– scavenger FeTPPS (10 mg/kg) during MI/R. Also, primarily cultured cardiomyocytes were subjected to hypoxia/re-oxygenation in the absence or presence of SIN-1 or FeTPPS. PPC conferred similar cardioprotection to IPC in reducing postischemic myocardial infarction compared to control. FeTPPS enhanced PPC cardioprotection while SIN-1 abolished PPC cardioprotection. HO-1 and p-STAT3 protein expression was increased in PPC group compared to control and it was associated with decreased ONOO– production and increased antioxidant capacity. PPC also attenuated post-hypoxic lactate dehydrogenase in vitro. However, HO-1/STAT3 gene knockdown abolished protective effect of PPC. In conclusion, PPC confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. | - |
dc.language | eng | en_US |
dc.publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ | - |
dc.relation.ispartof | The FASEB Journal | en_US |
dc.title | Propofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitrite | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Irwin, M: mgirwin@hku.hk | en_US |
dc.identifier.email | Wong, G: gordon@hku.hk | en_US |
dc.identifier.email | Xia, Z: zyxia@hkucc.hku.hk | en_US |
dc.identifier.authority | Irwin, M=rp00390 | en_US |
dc.identifier.authority | Wong, G=rp00523 | en_US |
dc.identifier.authority | Xia, Z=rp00532 | en_US |
dc.description.nature | abstract | - |
dc.identifier.doi | 10.1096/fasebj.27.1_supplement.lb619 | - |
dc.identifier.hkuros | 221912 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | S1 | - |
dc.identifier.spage | abstract no. lb619 | - |
dc.identifier.epage | abstract no. lb619 | - |
dc.identifier.isi | WOS:000319860502069 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0892-6638 | - |