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Conference Paper: Outcome of Haematopoietic Stem Cell Transplantation for children with Acute Myeloid Leukaemia in Hong Kong
Title | Outcome of Haematopoietic Stem Cell Transplantation for children with Acute Myeloid Leukaemia in Hong Kong |
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Authors | |
Issue Date | 2013 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society (HKPS) and Hong Kong Paediatric Nurses Association (HKPNA), Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 243 How to Cite? |
Abstract | Purpose: We aimed to review the outcomes of children
with acute myeloid leukaemia (AML) who received
allogeneic haematopoietic stem cell transplant (HSCT) in
Queen Mary Hospital.
Methods: We performed a retrospective review of all
children with AML who underwent allogeneic HSCT in the
past 20 years (1994-2013) and analysed their transplant
outcomes.
Results: We have performed allogeneic HSCT for 45
children (29 boys and 16 girls) with AML. The median age
at HSCT was 9.1 years (range, 0.8 to 18.5 years). Sixteen
children were transplanted in first complete remission (CR1),
20 in second remission (CR2), 1 in third remission (CR3),
and 8 with non-remission (NR). Donors were matched
sibling (MS) (n=19), 1-antigen mismatched parent (MP)
(n=2), matched unrelated donor (MUD) (n=11), or 4-6/6
HLA-matched unrelated cord blood (UCB) (single CB:
n=10, double CB: n=3). Five-year overall survival (OS) and
relapse-free survival (RFS) were 42.7% and 33.6%
respectively. Survivals differed significantly with remission
status (OS: 55% in CR1, 44.6% in CR2, vs. 14.3% in CR3/
NR; RFS: 55% in CR1, 24.2% in CR2, vs. 14.3% in CR3/
NR). OS but not RFS was significantly better in patients
who received UCB compared to MS, MUD, or MP (OS:
68.7% vs. 34.4% vs. 36.4% vs. 0%). OS and RFS were 100%
for patients with double cord blood transplant but the followup
was short (median 9 months). Transplant-related
mortalities in UCB, MS, MUD, and MP were 7.7%, 17.6%,
72.7% and 50% respectively.
Conclusion: Mortality remains high in children with
AML despite stem cell transplantation. Outcomes were
better for patients transplanted in first complete remission
and those who received unrelated cord blood, especially
double cord blood. |
Description | Poster Presentation (Doctor’s Session) |
Persistent Identifier | http://hdl.handle.net/10722/190129 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
DC Field | Value | Language |
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dc.contributor.author | Cheuk, KLD | en_US |
dc.contributor.author | Chiang, AKS | en_US |
dc.contributor.author | Ha, SY | en_US |
dc.contributor.author | Chan, GCF | en_US |
dc.date.accessioned | 2013-09-17T15:12:07Z | - |
dc.date.available | 2013-09-17T15:12:07Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 2013 Joint Annual Scientific Meeting of The Hong Kong Paediatric Society (HKPS) and Hong Kong Paediatric Nurses Association (HKPNA), Hong Kong, 8 September 2013. In Hong Kong Journal of Paediatrics (New series), 2013, v. 18 n. 4, p. 243 | en_US |
dc.identifier.issn | 1013-9923 | - |
dc.identifier.uri | http://hdl.handle.net/10722/190129 | - |
dc.description | Poster Presentation (Doctor’s Session) | - |
dc.description.abstract | Purpose: We aimed to review the outcomes of children with acute myeloid leukaemia (AML) who received allogeneic haematopoietic stem cell transplant (HSCT) in Queen Mary Hospital. Methods: We performed a retrospective review of all children with AML who underwent allogeneic HSCT in the past 20 years (1994-2013) and analysed their transplant outcomes. Results: We have performed allogeneic HSCT for 45 children (29 boys and 16 girls) with AML. The median age at HSCT was 9.1 years (range, 0.8 to 18.5 years). Sixteen children were transplanted in first complete remission (CR1), 20 in second remission (CR2), 1 in third remission (CR3), and 8 with non-remission (NR). Donors were matched sibling (MS) (n=19), 1-antigen mismatched parent (MP) (n=2), matched unrelated donor (MUD) (n=11), or 4-6/6 HLA-matched unrelated cord blood (UCB) (single CB: n=10, double CB: n=3). Five-year overall survival (OS) and relapse-free survival (RFS) were 42.7% and 33.6% respectively. Survivals differed significantly with remission status (OS: 55% in CR1, 44.6% in CR2, vs. 14.3% in CR3/ NR; RFS: 55% in CR1, 24.2% in CR2, vs. 14.3% in CR3/ NR). OS but not RFS was significantly better in patients who received UCB compared to MS, MUD, or MP (OS: 68.7% vs. 34.4% vs. 36.4% vs. 0%). OS and RFS were 100% for patients with double cord blood transplant but the followup was short (median 9 months). Transplant-related mortalities in UCB, MS, MUD, and MP were 7.7%, 17.6%, 72.7% and 50% respectively. Conclusion: Mortality remains high in children with AML despite stem cell transplantation. Outcomes were better for patients transplanted in first complete remission and those who received unrelated cord blood, especially double cord blood. | - |
dc.language | eng | en_US |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | - |
dc.relation.ispartof | Hong Kong Journal of Paediatrics (New series) | en_US |
dc.title | Outcome of Haematopoietic Stem Cell Transplantation for children with Acute Myeloid Leukaemia in Hong Kong | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Cheuk, KLD: klcheuk@hkucc.hku.hk | en_US |
dc.identifier.email | Chiang, AKS: chiangak@hku.hk | en_US |
dc.identifier.email | Ha, SY: syha@hku.hk | en_US |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | en_US |
dc.identifier.authority | Chiang, AKS=rp00403 | en_US |
dc.identifier.authority | Chan, GCF=rp00431 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 225083 | en_US |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 243 | en_US |
dc.identifier.epage | 243 | en_US |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1013-9923 | - |