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Conference Paper: An EBV microRNA targets DICE1 tumor suppressor gene

TitleAn EBV microRNA targets DICE1 tumor suppressor gene
Authors
Kok, KHLei, TJin, D
Issue Date2012
PublisherICOHAD 2012.
Citation
The 2012 International Congress on Oncogenic Herpesviruses and Associated Diseases (ICOHAD 2012), Philadelphia, PA., 1-4 August 2012. In Conference Program, 2012, p. 154, abstract no. 13.19 How to Cite?
AbstractMicroRNAs (miRNAs) play a critical role in post-transcriptional regulation of gene expression. Several herpesviruses have been shown to express viral miRNAs. Identification of the targets of these miRNAs might derive mechanistic insight into viral pathogenesis. We have previously demonstrated that Epstein-Barr virus (EBV)-encoded miR-BART5 targets p53-upregulated modulator of apoptosis (PUMA) in nasopharyngeal carcinoma (NPC) and this regulation is important for the EBV persistence and survival of EBV-infected cell survivals. In addition to the anti-apoptotic role of miR-BART5, other oncogenic activities of EBV miRNAs may also contribute to the development of lymphocytic or epithelial malignancies. In this study, we screened for potential targets of EBV miRNAs and found that EBV miR-BART3-5p potently suppressed the expression of DICE1 tumor suppressor in cultured cells. DICE1 is known …
DescriptionPoster Session 2: Host-Cell Interactions – Non-Coding RNA, Exosomes, and Epigenetics: no. 13.19
Persistent Identifierhttp://hdl.handle.net/10722/189764

 

DC FieldValueLanguage
dc.contributor.authorKok, KHen_US
dc.contributor.authorLei, Ten_US
dc.contributor.authorJin, Den_US
dc.date.accessioned2013-09-17T14:56:08Z-
dc.date.available2013-09-17T14:56:08Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 International Congress on Oncogenic Herpesviruses and Associated Diseases (ICOHAD 2012), Philadelphia, PA., 1-4 August 2012. In Conference Program, 2012, p. 154, abstract no. 13.19en_US
dc.identifier.urihttp://hdl.handle.net/10722/189764-
dc.descriptionPoster Session 2: Host-Cell Interactions – Non-Coding RNA, Exosomes, and Epigenetics: no. 13.19-
dc.description.abstractMicroRNAs (miRNAs) play a critical role in post-transcriptional regulation of gene expression. Several herpesviruses have been shown to express viral miRNAs. Identification of the targets of these miRNAs might derive mechanistic insight into viral pathogenesis. We have previously demonstrated that Epstein-Barr virus (EBV)-encoded miR-BART5 targets p53-upregulated modulator of apoptosis (PUMA) in nasopharyngeal carcinoma (NPC) and this regulation is important for the EBV persistence and survival of EBV-infected cell survivals. In addition to the anti-apoptotic role of miR-BART5, other oncogenic activities of EBV miRNAs may also contribute to the development of lymphocytic or epithelial malignancies. In this study, we screened for potential targets of EBV miRNAs and found that EBV miR-BART3-5p potently suppressed the expression of DICE1 tumor suppressor in cultured cells. DICE1 is known …-
dc.languageengen_US
dc.publisherICOHAD 2012.-
dc.relation.ispartofInternational Congress on Oncogenic Herpesviruses & Associated Diseases, ICOHAD 2012en_US
dc.titleAn EBV microRNA targets DICE1 tumor suppressor geneen_US
dc.typeConference_Paperen_US
dc.identifier.emailKok, KH: khkok@hku.hken_US
dc.identifier.emailLei, T: leiting@hku.hken_US
dc.identifier.emailJin, D: dyjin@hku.hk-
dc.identifier.authorityKok, KH=rp01455en_US
dc.identifier.authorityJin, D=rp00452en_US
dc.description.naturepostprint-
dc.identifier.hkuros224779en_US
dc.identifier.spage154, abstract no. 13.19-
dc.identifier.epage154, abstract no. 13.19-
dc.publisher.placeUnited States-

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