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- Publisher Website: 10.1586/erc.13.5
- Scopus: eid_2-s2.0-84876142343
- PMID: 23570363
- WOS: WOS:000216638100021
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Article: Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration
Title | Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration |
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Authors | |
Keywords | cardiovascular regeneration mechanisms mesenchymal stem cells therapy |
Issue Date | 2013 |
Citation | Expert Review of Cardiovascular Therapy, 2013, v. 11, p. 505-517 How to Cite? |
Abstract | Mesenchymal stem cells (MSCs) exhibit multipotent differentiation potential and can be derived from embryonic, neonatal and adult differentiation stage III tissue sources. While increasing preclinical studies and clinical trials have indicated that MSC-based therapy is a promising strategy for cardiovascular regeneration, there are major challenges to overcome before this stem-cell technology can be widely applied in clinical settings. In this review, the following important issues will be addressed. First, optimal sources of MSC derivation suitable for myocardial repair are not determined. Second, assessments for preclinical and clinical studies of MSCs require more scientific data analysis. Third, mechanisms of MSC-based therapy for cardiovascular regeneration have not been fully understood yet. Finally, the potential benefit-risk ratio of MSC therapy needs to be evaluated systematically. Additionally, future development of MSC therapy will be discussed. |
Persistent Identifier | http://hdl.handle.net/10722/189255 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.635 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ZHANG, Y | en_US |
dc.contributor.author | LIANG, X | en_US |
dc.contributor.author | Lian, Q | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.date.accessioned | 2013-09-17T14:30:59Z | - |
dc.date.available | 2013-09-17T14:30:59Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Expert Review of Cardiovascular Therapy, 2013, v. 11, p. 505-517 | en_US |
dc.identifier.issn | 1477-9072 | - |
dc.identifier.uri | http://hdl.handle.net/10722/189255 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) exhibit multipotent differentiation potential and can be derived from embryonic, neonatal and adult differentiation stage III tissue sources. While increasing preclinical studies and clinical trials have indicated that MSC-based therapy is a promising strategy for cardiovascular regeneration, there are major challenges to overcome before this stem-cell technology can be widely applied in clinical settings. In this review, the following important issues will be addressed. First, optimal sources of MSC derivation suitable for myocardial repair are not determined. Second, assessments for preclinical and clinical studies of MSCs require more scientific data analysis. Third, mechanisms of MSC-based therapy for cardiovascular regeneration have not been fully understood yet. Finally, the potential benefit-risk ratio of MSC therapy needs to be evaluated systematically. Additionally, future development of MSC therapy will be discussed. | - |
dc.language | eng | en_US |
dc.relation.ispartof | Expert Review of Cardiovascular Therapy | en_US |
dc.subject | cardiovascular regeneration | - |
dc.subject | mechanisms | - |
dc.subject | mesenchymal stem cells | - |
dc.subject | therapy | - |
dc.title | Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lian, Q: qzlian@hkucc.hku.hk | en_US |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | en_US |
dc.identifier.authority | Lian, Q=rp00267 | en_US |
dc.identifier.authority | Tse, HF=rp00428 | en_US |
dc.identifier.doi | 10.1586/erc.13.5 | - |
dc.identifier.pmid | 23570363 | - |
dc.identifier.scopus | eid_2-s2.0-84876142343 | - |
dc.identifier.hkuros | 223118 | en_US |
dc.identifier.hkuros | 225193 | - |
dc.identifier.hkuros | 241268 | - |
dc.identifier.volume | 11 | en_US |
dc.identifier.spage | 505 | en_US |
dc.identifier.epage | 517 | en_US |
dc.identifier.eissn | 1744-8344 | - |
dc.identifier.isi | WOS:000216638100021 | - |
dc.identifier.issnl | 1477-9072 | - |