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- PMID: 22443027
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Article: Effects of electroacupuncture on depression in a rat model
Title | Effects of electroacupuncture on depression in a rat model |
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Authors | |
Keywords | Acupuncture points Animal ehavioral test Animal model of depression Antidepressant treatment Depression Electrical stimulation Electroacupuncture Forced swimming Morris water maze Open field test Rats |
Issue Date | 2011 |
Citation | Acupuncture And Electro-Therapeutics Research, 2011, v. 36 n. 3-4, p. 259-273 How to Cite? |
Abstract | Objective To investigate the antidepressant-like effect of electroacupuncture (EA) in a validated rat model. Methods. Wistar Kyoto rats, a valid animal model of depression, were randomly divided into two groups, EA (n=7) and placebo control (n=6). EA treatment was given once a day, 5 days a week, for 3 weeks. Two acupoints, GV14 (Dazhui) and GV20 (Baihui), respectively on 2 the cervical spine and scalp, were selected. EA frequency was held constant at 2Hz (2 pulses/second), pulse width 0.3-ms, and intensity was adjusted to 3 mA. Forced swim tests (FST), open field tests (OFT; e.g., a. rearing and grooming, b. distance traveled within a central area, c. time spent in central area, and d. total distance traveled), and the Morris Water Maze test (MWM) were conducted 3 weeks after the initial treatment. Results. In the FST, there was significant difference between EA and control (P<0.05) in immobility. In the OFT, there were significant differences between EA and control (P<0.05) in rearing and grooming (P<0.05). In the MWM, there were significant differences between treatment and control in frequency of crossing the platform (P<0.05) and its surrounding area (P<0.05). Conclusion. Our data demonstrate that EA enhances memory and improves depression-related behaviors in a rat model of depression. This suggests that the modality may have therapeutic effects on depression in humans. Electroacupuncture may act on depression by protecting nerve cells in the hippocampus. Copyright © 2011 Cognizant Communication Corp. Printed in the USA. |
Persistent Identifier | http://hdl.handle.net/10722/188646 |
ISSN | 2023 Impact Factor: 0.2 2023 SCImago Journal Rankings: 0.128 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, S | en_US |
dc.contributor.author | Li, S | en_US |
dc.contributor.author | Shen, X | en_US |
dc.contributor.author | Meng, X | en_US |
dc.contributor.author | Lao, L | en_US |
dc.date.accessioned | 2013-09-03T04:10:50Z | - |
dc.date.available | 2013-09-03T04:10:50Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Acupuncture And Electro-Therapeutics Research, 2011, v. 36 n. 3-4, p. 259-273 | en_US |
dc.identifier.issn | 0360-1293 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188646 | - |
dc.description.abstract | Objective To investigate the antidepressant-like effect of electroacupuncture (EA) in a validated rat model. Methods. Wistar Kyoto rats, a valid animal model of depression, were randomly divided into two groups, EA (n=7) and placebo control (n=6). EA treatment was given once a day, 5 days a week, for 3 weeks. Two acupoints, GV14 (Dazhui) and GV20 (Baihui), respectively on 2 the cervical spine and scalp, were selected. EA frequency was held constant at 2Hz (2 pulses/second), pulse width 0.3-ms, and intensity was adjusted to 3 mA. Forced swim tests (FST), open field tests (OFT; e.g., a. rearing and grooming, b. distance traveled within a central area, c. time spent in central area, and d. total distance traveled), and the Morris Water Maze test (MWM) were conducted 3 weeks after the initial treatment. Results. In the FST, there was significant difference between EA and control (P<0.05) in immobility. In the OFT, there were significant differences between EA and control (P<0.05) in rearing and grooming (P<0.05). In the MWM, there were significant differences between treatment and control in frequency of crossing the platform (P<0.05) and its surrounding area (P<0.05). Conclusion. Our data demonstrate that EA enhances memory and improves depression-related behaviors in a rat model of depression. This suggests that the modality may have therapeutic effects on depression in humans. Electroacupuncture may act on depression by protecting nerve cells in the hippocampus. Copyright © 2011 Cognizant Communication Corp. Printed in the USA. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Acupuncture and Electro-Therapeutics Research | en_US |
dc.subject | Acupuncture points | - |
dc.subject | Animal ehavioral test | - |
dc.subject | Animal model of depression | - |
dc.subject | Antidepressant treatment | - |
dc.subject | Depression | - |
dc.subject | Electrical stimulation | - |
dc.subject | Electroacupuncture | - |
dc.subject | Forced swimming | - |
dc.subject | Morris water maze | - |
dc.subject | Open field test | - |
dc.subject | Rats | - |
dc.subject.mesh | Acupuncture Points | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Depression - Physiopathology - Psychology - Therapy | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Electroacupuncture | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Maze Learning | en_US |
dc.subject.mesh | Memory | en_US |
dc.subject.mesh | Random Allocation | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.subject.mesh | Swimming | en_US |
dc.title | Effects of electroacupuncture on depression in a rat model | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3727/036012911803634166 | - |
dc.identifier.pmid | 22443027 | - |
dc.identifier.scopus | eid_2-s2.0-84858168885 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84858168885&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 3-4 | en_US |
dc.identifier.spage | 259 | en_US |
dc.identifier.epage | 273 | en_US |
dc.identifier.isi | WOS:000300655000003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Xu, S=18435697200 | en_US |
dc.identifier.scopusauthorid | Li, S=36063540000 | en_US |
dc.identifier.scopusauthorid | Shen, X=7402721090 | en_US |
dc.identifier.scopusauthorid | Meng, X=53064279800 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.issnl | 0360-1293 | - |