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- Publisher Website: 10.3233/JAD-2009-1189
- Scopus: eid_2-s2.0-74949110261
- PMID: 19661619
- WOS: WOS:000272863500005
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Article: Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
Title | Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons |
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Authors | |
Keywords | Amyloid-beta derived diffusible ligands (ADDL) Bilobalide CREB Neurogenesis Quercetin Synaptogenesis |
Issue Date | 2009 |
Publisher | IOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php |
Citation | Journal Of Alzheimer's Disease, 2009, v. 18 n. 4, p. 787-798 How to Cite? |
Abstract | Loss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of AD. Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. This study aims to identify the constituents that contribute to EGb 761-induced neurogenesis. Among the constituents tested, bilobalide and quercetin significantly increased cell proliferation in the hippocampal neurons in a dose-dependent manner. Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain. Immunofluorescence staining of synaptic markers shows remarkable dendritic processes in hippocampal neurons treated with either quercetin or bilobalide. Furthermore, both constituents restored amyloid-β oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB. The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB. Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation. © 2009-IOS Press and the authors. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188615 |
ISSN | 2021 Impact Factor: 4.160 2020 SCImago Journal Rankings: 1.677 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tchantchou, F | en_US |
dc.contributor.author | Lacor, PN | en_US |
dc.contributor.author | Cao, Z | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Hou, Y | en_US |
dc.contributor.author | Cui, C | en_US |
dc.contributor.author | Klein, WL | en_US |
dc.contributor.author | Luo, Y | en_US |
dc.date.accessioned | 2013-09-03T04:10:38Z | - |
dc.date.available | 2013-09-03T04:10:38Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Journal Of Alzheimer's Disease, 2009, v. 18 n. 4, p. 787-798 | en_US |
dc.identifier.issn | 1387-2877 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188615 | - |
dc.description.abstract | Loss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of AD. Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. This study aims to identify the constituents that contribute to EGb 761-induced neurogenesis. Among the constituents tested, bilobalide and quercetin significantly increased cell proliferation in the hippocampal neurons in a dose-dependent manner. Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain. Immunofluorescence staining of synaptic markers shows remarkable dendritic processes in hippocampal neurons treated with either quercetin or bilobalide. Furthermore, both constituents restored amyloid-β oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB. The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB. Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation. © 2009-IOS Press and the authors. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | IOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php | en_US |
dc.relation.ispartof | Journal of Alzheimer's Disease | en_US |
dc.subject | Amyloid-beta derived diffusible ligands (ADDL) | - |
dc.subject | Bilobalide | - |
dc.subject | CREB | - |
dc.subject | Neurogenesis | - |
dc.subject | Quercetin | - |
dc.subject | Synaptogenesis | - |
dc.subject.mesh | Alzheimer Disease - Drug Therapy - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blotting, Western | en_US |
dc.subject.mesh | Cyclic Amp Response Element-Binding Protein - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Cyclopentanes - Pharmacology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Furans - Pharmacology | en_US |
dc.subject.mesh | Ginkgolides - Pharmacology | en_US |
dc.subject.mesh | Hippocampus - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Neurogenesis - Drug Effects | en_US |
dc.subject.mesh | Phosphorylation | en_US |
dc.subject.mesh | Plant Extracts - Pharmacology | en_US |
dc.subject.mesh | Quercetin - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Synapses - Drug Effects | en_US |
dc.title | Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3233/JAD-2009-1189 | en_US |
dc.identifier.pmid | 19661619 | - |
dc.identifier.scopus | eid_2-s2.0-74949110261 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-74949110261&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 787 | en_US |
dc.identifier.epage | 798 | en_US |
dc.identifier.isi | WOS:000272863500005 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Tchantchou, F=6506692750 | en_US |
dc.identifier.scopusauthorid | Lacor, PN=7004574259 | en_US |
dc.identifier.scopusauthorid | Cao, Z=8741147700 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Hou, Y=36716080300 | en_US |
dc.identifier.scopusauthorid | Cui, C=7201920204 | en_US |
dc.identifier.scopusauthorid | Klein, WL=7402435293 | en_US |
dc.identifier.scopusauthorid | Luo, Y=55712616300 | en_US |
dc.identifier.issnl | 1387-2877 | - |