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- Publisher Website: 10.1097/WNR.0b013e3280586839
- Scopus: eid_2-s2.0-34247593035
- PMID: 17496810
- WOS: WOS:000245440900019
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Article: Interleukin-1ra inhibits Fos expression and hyperalgesia in rats
Title | Interleukin-1ra inhibits Fos expression and hyperalgesia in rats |
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Authors | |
Keywords | Fos Hyperalgesia Interleukin-1β Interleukin-1ra Intrathecal Rats Spinal cord |
Issue Date | 2007 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com |
Citation | Neuroreport, 2007, v. 18 n. 5, p. 495-498 How to Cite? |
Abstract | It is known that interleukin-1β facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1β in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-receptor antagonist (interleukin-1ra, 0.005 mg/rat) was given intrathecally twice, 24 h before complete Freund's adjuvant and immediately before complete Freund's adjuvant injection, to block interleukin-1β action. Fos expression was measured 2 h after complete Freund's adjuvant injection. Paw withdrawal latency was used to assess hyperalgesia. The findings were that interleukin-1ra inhibited inflammation-induced Fos expression and hyperalgesia, which suggests that endogenous interleukin-1β facilitates transmission of noxious messages at the spinal level by processes involving an enhanced Fos expression. © 2007 Lippincott Williams & Wilkins, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/188586 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.459 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, A | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Wang, Y | en_US |
dc.contributor.author | Zhang, H | en_US |
dc.contributor.author | Ren, K | en_US |
dc.contributor.author | Berman, BM | en_US |
dc.contributor.author | Zhang, R | en_US |
dc.date.accessioned | 2013-09-03T04:10:27Z | - |
dc.date.available | 2013-09-03T04:10:27Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Neuroreport, 2007, v. 18 n. 5, p. 495-498 | en_US |
dc.identifier.issn | 0959-4965 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188586 | - |
dc.description.abstract | It is known that interleukin-1β facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1β in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-receptor antagonist (interleukin-1ra, 0.005 mg/rat) was given intrathecally twice, 24 h before complete Freund's adjuvant and immediately before complete Freund's adjuvant injection, to block interleukin-1β action. Fos expression was measured 2 h after complete Freund's adjuvant injection. Paw withdrawal latency was used to assess hyperalgesia. The findings were that interleukin-1ra inhibited inflammation-induced Fos expression and hyperalgesia, which suggests that endogenous interleukin-1β facilitates transmission of noxious messages at the spinal level by processes involving an enhanced Fos expression. © 2007 Lippincott Williams & Wilkins, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com | en_US |
dc.relation.ispartof | NeuroReport | en_US |
dc.subject | Fos | - |
dc.subject | Hyperalgesia | - |
dc.subject | Interleukin-1β | - |
dc.subject | Interleukin-1ra | - |
dc.subject | Intrathecal | - |
dc.subject | Rats | - |
dc.subject | Spinal cord | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Freund's Adjuvant | en_US |
dc.subject.mesh | Functional Laterality - Physiology | en_US |
dc.subject.mesh | Gene Expression Regulation - Drug Effects | en_US |
dc.subject.mesh | Hyperalgesia - Chemically Induced - Prevention & Control | en_US |
dc.subject.mesh | Interleukin 1 Receptor Antagonist Protein - Therapeutic Use | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pain Measurement - Methods | en_US |
dc.subject.mesh | Proto-Oncogene Proteins C-Fos - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.title | Interleukin-1ra inhibits Fos expression and hyperalgesia in rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/WNR.0b013e3280586839 | en_US |
dc.identifier.pmid | 17496810 | - |
dc.identifier.scopus | eid_2-s2.0-34247593035 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34247593035&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 495 | en_US |
dc.identifier.epage | 498 | en_US |
dc.identifier.isi | WOS:000245440900019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, A=16245342100 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Wang, Y=7601488320 | en_US |
dc.identifier.scopusauthorid | Zhang, H=51563012400 | en_US |
dc.identifier.scopusauthorid | Ren, K=7102272533 | en_US |
dc.identifier.scopusauthorid | Berman, BM=35458606800 | en_US |
dc.identifier.scopusauthorid | Zhang, R=7404864527 | en_US |
dc.identifier.issnl | 0959-4965 | - |