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Article: Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation

TitleEffects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation
Authors
Zhang, RXLao, LQiao, JTRuda, MA
KeywordsFreund's adjuvant
Inflammation
Persistent pain
Serotonin
Spinal cord
Substance P
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2004, v. 999 n. 1, p. 135-141 How to Cite?
DOI: http://dx.doi.org/10.1016/j.brainres.2003.11.042
AbstractThe aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain. © 2003 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188561
ISSN
0006-8993
2021 Impact Factor: 3.610
2020 SCImago Journal Rankings: 1.037
ISI Accession Number ID
WOS:000189091200016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorQiao, JTen_US
dc.contributor.authorRuda, MAen_US
dc.date.accessioned2013-09-03T04:10:17Z-
dc.date.available2013-09-03T04:10:17Z-
dc.date.issued2004en_US
dc.identifier.citationBrain Research, 2004, v. 999 n. 1, p. 135-141en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/188561-
dc.description.abstractThe aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain. © 2003 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subjectFreund's adjuvant-
dc.subjectInflammation-
dc.subjectPersistent pain-
dc.subjectSerotonin-
dc.subjectSpinal cord-
dc.subjectSubstance P-
dc.subject.meshAging - Metabolism - Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDynorphins - Genetics - Metabolismen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshFunctional Laterality - Physiologyen_US
dc.subject.meshHyperalgesia - Chemically Induced - Metabolism - Physiopathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInflammation - Chemically Induced - Metabolism - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPeripheral Nervous System Diseases - Metabolism - Physiopathologyen_US
dc.subject.meshPhysical Stimulationen_US
dc.subject.meshPosterior Horn Cells - Metabolismen_US
dc.subject.meshProtein Precursors - Geneticsen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshUp-Regulation - Physiologyen_US
dc.titleEffects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2003.11.042en_US
dc.identifier.pmid14746931-
dc.identifier.scopuseid_2-s2.0-1642513492en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642513492&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume999en_US
dc.identifier.issue1en_US
dc.identifier.spage135en_US
dc.identifier.epage141en_US
dc.identifier.isiWOS:000189091200016-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridQiao, JT=7103301572en_US
dc.identifier.scopusauthoridRuda, MA=7005152163en_US
dc.identifier.issnl0006-8993-

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