File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S0091-3057(97)00017-8
- Scopus: eid_2-s2.0-0030839424
- PMID: 9264088
- WOS: WOS:A1997XP13500027
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Biphasic emetic response of cyclophosphamide in the ferret
Title | Biphasic emetic response of cyclophosphamide in the ferret |
---|---|
Authors | |
Keywords | Cyclophosphamide Droperidol Emesis Ferret Metaclopramide Ondansetron |
Issue Date | 1997 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh |
Citation | Pharmacology Biochemistry And Behavior, 1997, v. 58 n. 1, p. 179-182 How to Cite? |
Abstract | Cyclophosphamide (177 mg/kg, IV; n = 8) produced it biphasic emetic response in the ferret with a mean ± SE of 23.3 + 4.0 emetic episodes during a 4-h observation period. The emetic profile of cyclophosphamide showed a first phase with 18.6 ± 3.9 episodes and a second phase with 4.7 ± 1.2 episodes. Ondansetron (0.07 and 0.13 mg/kg, IV) and droperidol (0.25 and 0.79 mg/kg, IV) significantly reduced the number of emetic episodes in the first phase. Metoclopramide (2.24, 4.08, and 7.07 mg/kg, IV) also significantly reduced the number of emetic episodes in the first phase, and the dose of 7.07 mg/kg completely prevented emetic episodes in the second phase. In addition, ondansetron-treated ferrets (0.04, 0.07, and 0.13 mg/kg, IV) had a significant increase in the number of emetic episodes in the second phase. |
Persistent Identifier | http://hdl.handle.net/10722/188531 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.050 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, RH | en_US |
dc.contributor.author | Lao, L | en_US |
dc.contributor.author | Berman, BM | en_US |
dc.contributor.author | Carter, AK | en_US |
dc.contributor.author | Wynn, RL | en_US |
dc.date.accessioned | 2013-09-03T04:10:08Z | - |
dc.date.available | 2013-09-03T04:10:08Z | - |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | Pharmacology Biochemistry And Behavior, 1997, v. 58 n. 1, p. 179-182 | en_US |
dc.identifier.issn | 0091-3057 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188531 | - |
dc.description.abstract | Cyclophosphamide (177 mg/kg, IV; n = 8) produced it biphasic emetic response in the ferret with a mean ± SE of 23.3 + 4.0 emetic episodes during a 4-h observation period. The emetic profile of cyclophosphamide showed a first phase with 18.6 ± 3.9 episodes and a second phase with 4.7 ± 1.2 episodes. Ondansetron (0.07 and 0.13 mg/kg, IV) and droperidol (0.25 and 0.79 mg/kg, IV) significantly reduced the number of emetic episodes in the first phase. Metoclopramide (2.24, 4.08, and 7.07 mg/kg, IV) also significantly reduced the number of emetic episodes in the first phase, and the dose of 7.07 mg/kg completely prevented emetic episodes in the second phase. In addition, ondansetron-treated ferrets (0.04, 0.07, and 0.13 mg/kg, IV) had a significant increase in the number of emetic episodes in the second phase. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh | en_US |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior | en_US |
dc.subject | Cyclophosphamide | - |
dc.subject | Droperidol | - |
dc.subject | Emesis | - |
dc.subject | Ferret | - |
dc.subject | Metaclopramide | - |
dc.subject | Ondansetron | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antiemetics - Pharmacology | en_US |
dc.subject.mesh | Antineoplastic Agents, Alkylating - Administration & Dosage - Antagonists & Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Cyclophosphamide - Administration & Dosage - Antagonists & Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Droperidol - Pharmacology | en_US |
dc.subject.mesh | Ferrets - Physiology | en_US |
dc.subject.mesh | Injections, Intravenous | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Metoclopramide - Pharmacology | en_US |
dc.subject.mesh | Ondansetron - Pharmacology | en_US |
dc.subject.mesh | Vomiting - Chemically Induced | en_US |
dc.title | Biphasic emetic response of cyclophosphamide in the ferret | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0091-3057(97)00017-8 | en_US |
dc.identifier.pmid | 9264088 | - |
dc.identifier.scopus | eid_2-s2.0-0030839424 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030839424&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 179 | en_US |
dc.identifier.epage | 182 | en_US |
dc.identifier.isi | WOS:A1997XP13500027 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wong, RH=7402126848 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.scopusauthorid | Berman, BM=35458606800 | en_US |
dc.identifier.scopusauthorid | Carter, AK=16678419200 | en_US |
dc.identifier.scopusauthorid | Wynn, RL=19537208500 | en_US |
dc.identifier.issnl | 0091-3057 | - |