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Conference Paper: Developmental toxicity of one marine dinoflagellate toxicant-saxitoxin
Title | Developmental toxicity of one marine dinoflagellate toxicant-saxitoxin |
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Authors | |
Issue Date | 2013 |
Publisher | Georg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html |
Citation | The 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, NY., 1 August 2012. In Planta Medica, 2012, n. 11, v. 78, abstract PI9 How to Cite? |
Abstract | Saxitoxin (STX), found mainly in marine dinoflagellates, is one water-soluble neurotoxin. When some fishes accumulate STX and are consumed by humans, it would cause a series of diseases, especially to children. STX was known to possess high binding affinity to the soluble sites of sodium channels and interrupts the propagation of neuronal impulses by blocking the sodium channel in excitable cells, however, it still remain unknown whether STX can contribute to other toxic effects or not. In our current study, we adopted medaka fish (Oryzias melastigma) embryos as model animals to study its developmental toxicity to children. By detecting the protein markers using 2-D electrophoresis combined with MALDI TOF/TOF MS, we found that STX could accelerate the embryonic development by enhancing the expression of stress related proteins and metabolism proteins, and by regulating phosphorylation processes. |
Description | This journal issue entitled: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ... 2012. The abstracts' web site is located at https://www.thieme-connect.de/ejournals/issue/10.1055/s-002-23510/grouping/020261/10.1055/s-00000058 Poster - Topic I: Natural Products Discovery: Marine, Microbes, Plants and other: abstract PI9 |
Persistent Identifier | http://hdl.handle.net/10722/188009 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.445 |
DC Field | Value | Language |
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dc.contributor.author | Tian, L | en_US |
dc.contributor.author | Wang, M | - |
dc.date.accessioned | 2013-08-21T07:24:48Z | - |
dc.date.available | 2013-08-21T07:24:48Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, NY., 1 August 2012. In Planta Medica, 2012, n. 11, v. 78, abstract PI9 | en_US |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10722/188009 | - |
dc.description | This journal issue entitled: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ... 2012. The abstracts' web site is located at https://www.thieme-connect.de/ejournals/issue/10.1055/s-002-23510/grouping/020261/10.1055/s-00000058 | - |
dc.description | Poster - Topic I: Natural Products Discovery: Marine, Microbes, Plants and other: abstract PI9 | - |
dc.description.abstract | Saxitoxin (STX), found mainly in marine dinoflagellates, is one water-soluble neurotoxin. When some fishes accumulate STX and are consumed by humans, it would cause a series of diseases, especially to children. STX was known to possess high binding affinity to the soluble sites of sodium channels and interrupts the propagation of neuronal impulses by blocking the sodium channel in excitable cells, however, it still remain unknown whether STX can contribute to other toxic effects or not. In our current study, we adopted medaka fish (Oryzias melastigma) embryos as model animals to study its developmental toxicity to children. By detecting the protein markers using 2-D electrophoresis combined with MALDI TOF/TOF MS, we found that STX could accelerate the embryonic development by enhancing the expression of stress related proteins and metabolism proteins, and by regulating phosphorylation processes. | - |
dc.language | eng | en_US |
dc.publisher | Georg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html | - |
dc.relation.ispartof | Planta Medica | en_US |
dc.rights | Planta Medica. Copyright © Georg Thieme Verlag. | - |
dc.title | Developmental toxicity of one marine dinoflagellate toxicant-saxitoxin | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wang, M: mfwang@hku.hk | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1055/s-0032-1320696 | - |
dc.identifier.hkuros | 219649 | en_US |
dc.identifier.volume | 78 | - |
dc.identifier.issue | 11 | - |
dc.publisher.place | Germany | en_US |
dc.customcontrol.immutable | sml 130911 | - |
dc.identifier.issnl | 0032-0943 | - |