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Article: A powerful parent-of-origin effects test for qualitative traits incorporating control children in nuclear families

TitleA powerful parent-of-origin effects test for qualitative traits incorporating control children in nuclear families
Authors
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal of Human Genetics, 2012, v. 57 n. 8, p. 500-507 How to Cite?
AbstractGenomic imprinting is an important epigenetic phenomenon in studying complex traits and has generally been examined by detecting parent-of-origin effects of alleles. The parental-asymmetry test (PAT) based on nuclear families with both parents and its extensions to deal with missing parental genotypes is simple and powerful for such a task. However, these methods only use case (affected) children in nuclear families and thus do not make full use of information on control (unaffected) children, if available, in these families. In this article, we propose a novel parent-of-origin effects test C-PATu (the combined test of PATu and 1-PATu) by using both the control and case children in nuclear families with one or both parents. C-PATu is essentially a weighted framework, in which the test based on all the control children and their parents and that based on all the case children and their parents are weighted according to the population disease prevalence. Simulation results demonstrate that the proposed tests control the size well under no parent-of-origin effects and using additional information from control children improves the power of the tests under the imprinting alternative. Application of C-PATu to a Framingham Heart Study data set further shows the feasibility in practical application of the test.
Persistent Identifierhttp://hdl.handle.net/10722/184724
ISSN
2020 Impact Factor: 3.172
2020 SCImago Journal Rankings: 1.055

 

DC FieldValueLanguage
dc.contributor.authorZhou, JY-
dc.contributor.authorMao, WG-
dc.contributor.authorLi, DL-
dc.contributor.authorHu, YQ-
dc.contributor.authorXia, F-
dc.contributor.authorFung, TWK-
dc.date.accessioned2013-07-15T10:06:27Z-
dc.date.available2013-07-15T10:06:27Z-
dc.date.issued2012-
dc.identifier.citationJournal of Human Genetics, 2012, v. 57 n. 8, p. 500-507-
dc.identifier.issn1434-5161-
dc.identifier.urihttp://hdl.handle.net/10722/184724-
dc.description.abstractGenomic imprinting is an important epigenetic phenomenon in studying complex traits and has generally been examined by detecting parent-of-origin effects of alleles. The parental-asymmetry test (PAT) based on nuclear families with both parents and its extensions to deal with missing parental genotypes is simple and powerful for such a task. However, these methods only use case (affected) children in nuclear families and thus do not make full use of information on control (unaffected) children, if available, in these families. In this article, we propose a novel parent-of-origin effects test C-PATu (the combined test of PATu and 1-PATu) by using both the control and case children in nuclear families with one or both parents. C-PATu is essentially a weighted framework, in which the test based on all the control children and their parents and that based on all the case children and their parents are weighted according to the population disease prevalence. Simulation results demonstrate that the proposed tests control the size well under no parent-of-origin effects and using additional information from control children improves the power of the tests under the imprinting alternative. Application of C-PATu to a Framingham Heart Study data set further shows the feasibility in practical application of the test.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html-
dc.relation.ispartofJournal of Human Genetics-
dc.subject.meshData Interpretation, Statistical-
dc.subject.meshEpigenesis, Genetic-
dc.subject.meshGenomic Imprinting-
dc.subject.meshHeart Diseases - genetics-
dc.subject.meshModels, Genetic-
dc.titleA powerful parent-of-origin effects test for qualitative traits incorporating control children in nuclear families-
dc.typeArticle-
dc.identifier.emailFung, TWK: wingfung@hku.hk-
dc.identifier.authorityFung, TWK=rp00696-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/jhg.2012.58-
dc.identifier.pmid22648181-
dc.identifier.scopuseid_2-s2.0-84865691259-
dc.identifier.hkuros216122-
dc.identifier.volume57-
dc.identifier.issue8-
dc.identifier.spage500-
dc.identifier.epage507-
dc.publisher.placeUnited Kingdom-

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