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Article: Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up

TitleCapsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up
Authors
Issue Date2012
PublisherWolters Kluwer Health. The Journal's web site is located at https://journals.lww.com/ajg/pages/default.aspx
Citation
American Journal of Gastroenterology, 2012, v. 107 n. 9, p. 1370-1376 How to Cite?
AbstractOBJECTIVES: Both capsule endoscopy (CE) and angiography have been recommended as first investigation for patients with acute overt obscure gastrointestinal bleeding (OGIB). However, no studies have directly compared the two modalities in patients with overt OGIB. We compared the diagnostic yield and long-term outcomes of patients with overt OGIB randomized to CE or angiogram. METHODS: Consecutive patients presented with acute melena or hematochezia, but nondiagnostic upper and lower endoscopy, were immediately randomized to receive small-bowel CE or angiography. All patients were monitored for rebleeding and anemia for up to 5 years. Primary end point was the diagnostic yield of the assigned investigation. Secondary end points included rebleeding, further transfusion, readmission for bleeding or anemia, and mortality. RESULTS: A total of 60 patients with overt OGIB were randomized. The mean follow-up was 48.5 months. The diagnostic yield of immediate CE was significantly higher than angiography (53.3% vs. 20.0%, P = 0.016). The cumulative risk of rebleeding in the angiography and CE group was 33.3% and 16.7%, respectively (P = 0.10, log-rank test). There was no significant difference in the long-term outcomes between the two groups including further transfusion, hospitalization for rebleeding, and mortality. CONCLUSIONS: In patients with overt OGIB, immediate CE has higher diagnostic yield and comparable long-term outcomes when compared with angiography.
Persistent Identifierhttp://hdl.handle.net/10722/184582
ISSN
2023 Impact Factor: 8.0
2023 SCImago Journal Rankings: 2.391
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorHo, SSM-
dc.contributor.authorSuen, BY-
dc.contributor.authorLai, LH-
dc.contributor.authorYu, S-
dc.contributor.authorNg, EKW-
dc.contributor.authorNg, SSM-
dc.contributor.authorChiu, PWY-
dc.contributor.authorSung, JJY-
dc.contributor.authorChan, FKL-
dc.contributor.authorLau, JYW-
dc.date.accessioned2013-07-15T09:56:29Z-
dc.date.available2013-07-15T09:56:29Z-
dc.date.issued2012-
dc.identifier.citationAmerican Journal of Gastroenterology, 2012, v. 107 n. 9, p. 1370-1376-
dc.identifier.issn0002-9270-
dc.identifier.urihttp://hdl.handle.net/10722/184582-
dc.description.abstractOBJECTIVES: Both capsule endoscopy (CE) and angiography have been recommended as first investigation for patients with acute overt obscure gastrointestinal bleeding (OGIB). However, no studies have directly compared the two modalities in patients with overt OGIB. We compared the diagnostic yield and long-term outcomes of patients with overt OGIB randomized to CE or angiogram. METHODS: Consecutive patients presented with acute melena or hematochezia, but nondiagnostic upper and lower endoscopy, were immediately randomized to receive small-bowel CE or angiography. All patients were monitored for rebleeding and anemia for up to 5 years. Primary end point was the diagnostic yield of the assigned investigation. Secondary end points included rebleeding, further transfusion, readmission for bleeding or anemia, and mortality. RESULTS: A total of 60 patients with overt OGIB were randomized. The mean follow-up was 48.5 months. The diagnostic yield of immediate CE was significantly higher than angiography (53.3% vs. 20.0%, P = 0.016). The cumulative risk of rebleeding in the angiography and CE group was 33.3% and 16.7%, respectively (P = 0.10, log-rank test). There was no significant difference in the long-term outcomes between the two groups including further transfusion, hospitalization for rebleeding, and mortality. CONCLUSIONS: In patients with overt OGIB, immediate CE has higher diagnostic yield and comparable long-term outcomes when compared with angiography.-
dc.languageeng-
dc.publisherWolters Kluwer Health. The Journal's web site is located at https://journals.lww.com/ajg/pages/default.aspx-
dc.relation.ispartofAmerican Journal of Gastroenterology-
dc.subject.meshAngiography-
dc.subject.meshCapsule Endoscopy-
dc.subject.meshGastrointestinal Hemorrhage - diagnosis - radiography-
dc.subject.meshIntestine, Small - radiography-
dc.subject.meshMelena - diagnosis - radiography-
dc.titleCapsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up-
dc.typeArticle-
dc.identifier.emailLeung, WK: hku75407@hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajg.2012.212-
dc.identifier.pmid22825363-
dc.identifier.scopuseid_2-s2.0-84866099220-
dc.identifier.hkuros216074-
dc.identifier.volume107-
dc.identifier.issue9-
dc.identifier.spage1370-
dc.identifier.epage1376-
dc.identifier.isiWOS:000308689200013-
dc.publisher.placeUnited States-
dc.identifier.f1000717973656-

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