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Article: Sublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term
Title | Sublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term |
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Authors | |
Keywords | Cervix uteri Induced Labor Misoprostol Oxytocin |
Issue Date | 2006 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk |
Citation | Hong Kong Medical Journal, 2006, v. 12 n. 5, p. 345-350 How to Cite? |
Abstract | Objectives. To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term. Design. Open randomised controlled trial. Setting. Regional hospital, Hong Kong. Patients. Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indications for labour induction. Interventions. With their informed consent, 100 eligible women were to be randomised to receive either sublingual misoprostol 50 μg every 4 hours for up to five doses or oxytocin infusion after artificial rupture of membranes. Interim analysis was planned at a sample size of 50. Main outcome measures. Vaginal delivery within 24 hours of induction. Results. The study was terminated when interim analysis of the first 50 recruits showed that a significantly smaller proportion of misoprostol-treated women delivered vaginally within 24 hours of induction than in the conventional treatment group (68% vs 100%; relative risk, 0.68; 95% confidence interval, 0.51-0.91; P=0.009), although comparable numbers of women eventually delivered vaginally. The mean induction to vaginal delivery interval was 4.5 hours longer in the misoprostol group (P=0.027). After misoprostol treatment, all women went into labour. Forty percent of them delivered without oxytocin. There was no significant difference in uterine hyperstimulation rate, operative delivery rate, and neonatal outcomes. Maternal satisfaction was higher in the misoprostol group (92% vs 60%; relative risk, 1.53; 95% confidence interval, 1.09-2.16; P=0.008). Conclusions. Despite being well accepted by women, labour induction using this regimen of sublingual misoprostol is less effective in achieving vaginal delivery within 24 hours. |
Persistent Identifier | http://hdl.handle.net/10722/184208 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lo, TK | en_US |
dc.contributor.author | Lau, WL | en_US |
dc.contributor.author | Wong, KS | en_US |
dc.contributor.author | Tang, LCH | en_US |
dc.date.accessioned | 2013-06-25T03:01:23Z | - |
dc.date.available | 2013-06-25T03:01:23Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Hong Kong Medical Journal, 2006, v. 12 n. 5, p. 345-350 | en_US |
dc.identifier.issn | 1024-2708 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/184208 | - |
dc.description.abstract | Objectives. To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term. Design. Open randomised controlled trial. Setting. Regional hospital, Hong Kong. Patients. Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indications for labour induction. Interventions. With their informed consent, 100 eligible women were to be randomised to receive either sublingual misoprostol 50 μg every 4 hours for up to five doses or oxytocin infusion after artificial rupture of membranes. Interim analysis was planned at a sample size of 50. Main outcome measures. Vaginal delivery within 24 hours of induction. Results. The study was terminated when interim analysis of the first 50 recruits showed that a significantly smaller proportion of misoprostol-treated women delivered vaginally within 24 hours of induction than in the conventional treatment group (68% vs 100%; relative risk, 0.68; 95% confidence interval, 0.51-0.91; P=0.009), although comparable numbers of women eventually delivered vaginally. The mean induction to vaginal delivery interval was 4.5 hours longer in the misoprostol group (P=0.027). After misoprostol treatment, all women went into labour. Forty percent of them delivered without oxytocin. There was no significant difference in uterine hyperstimulation rate, operative delivery rate, and neonatal outcomes. Maternal satisfaction was higher in the misoprostol group (92% vs 60%; relative risk, 1.53; 95% confidence interval, 1.09-2.16; P=0.008). Conclusions. Despite being well accepted by women, labour induction using this regimen of sublingual misoprostol is less effective in achieving vaginal delivery within 24 hours. | en_US |
dc.language | eng | en_US |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk | en_US |
dc.relation.ispartof | Hong Kong Medical Journal | en_US |
dc.subject | Cervix uteri | - |
dc.subject | Induced | - |
dc.subject | Labor | - |
dc.subject | Misoprostol | - |
dc.subject | Oxytocin | - |
dc.subject.mesh | Administration, Sublingual | en_US |
dc.subject.mesh | Cervix Uteri - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Labor, Induced | en_US |
dc.subject.mesh | Misoprostol - Administration & Dosage | en_US |
dc.subject.mesh | Oxytocics - Administration & Dosage | en_US |
dc.subject.mesh | Oxytocin - Administration & Dosage | en_US |
dc.subject.mesh | Parity | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.title | Sublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, LCH: lchtang@hku.hk | en_US |
dc.identifier.authority | Tang, LCH=rp01756 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 17028353 | - |
dc.identifier.scopus | eid_2-s2.0-33750051036 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33750051036&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 345 | en_US |
dc.identifier.epage | 350 | en_US |
dc.publisher.place | Hong Kong | en_US |
dc.identifier.scopusauthorid | Lo, TK=7203076032 | en_US |
dc.identifier.scopusauthorid | Lau, WL=12142218500 | en_US |
dc.identifier.scopusauthorid | Wong, KS=36341790700 | en_US |
dc.identifier.scopusauthorid | Tang, LCH=7402081111 | en_US |
dc.identifier.issnl | 1024-2708 | - |