File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Infection fatality risk of the pandemic A(H1N1)2009 virus in Hong Kong

TitleInfection fatality risk of the pandemic A(H1N1)2009 virus in Hong Kong
Authors
Keywordsdeath
human influenza
severity
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
Citation
American Journal of Epidemiology, 2013, v. 177 n. 8, p. 834-40 How to Cite?
AbstractOne measure of the severity of a pandemic influenza outbreak at the individual level is the risk of death among people infected by the new virus. However, there are complications in estimating both the numerator and denominator. Regarding the numerator, statistical estimates of the excess deaths associated with influenza virus infections tend to exceed the number of deaths associated with laboratory-confirmed infection. Regarding the denominator, few infections are laboratory confirmed, while differences in case definitions and approaches to case ascertainment can lead to wide variation in case fatality risk estimates. Serological surveillance can be used to estimate the cumulative incidence of infection as a denominator that is more comparable across studies. We estimated that the first wave of the influenza A(H1N1)pdm09 virus in 2009 was associated with approximately 232 (95% confidence interval: 136, 328) excess deaths of all ages in Hong Kong, mainly among the elderly. The point estimates of the risk of death on a per-infection basis increased substantially with age, from below 1 per 100,000 infections in children to 1,099 per 100,000 infections in those 60-69 years of age. Substantial variation in the age-specific infection fatality risk complicates comparison of the severity of different influenza strains. © 2013 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/184035
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 0.837
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YTen_US
dc.contributor.authorWu, Pen_US
dc.contributor.authorNishiura, Hen_US
dc.contributor.authorGoldstein, Een_US
dc.contributor.authorLau, EHYen_US
dc.contributor.authorYang, Len_US
dc.contributor.authorChuang, SKen_US
dc.contributor.authorTsang, THFen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorWu, JTKen_US
dc.contributor.authorCowling, BJen_US
dc.date.accessioned2013-06-18T04:42:37Z-
dc.date.available2013-06-18T04:42:37Z-
dc.date.issued2013en_US
dc.identifier.citationAmerican Journal of Epidemiology, 2013, v. 177 n. 8, p. 834-40en_US
dc.identifier.issn0002-9262-
dc.identifier.urihttp://hdl.handle.net/10722/184035-
dc.description.abstractOne measure of the severity of a pandemic influenza outbreak at the individual level is the risk of death among people infected by the new virus. However, there are complications in estimating both the numerator and denominator. Regarding the numerator, statistical estimates of the excess deaths associated with influenza virus infections tend to exceed the number of deaths associated with laboratory-confirmed infection. Regarding the denominator, few infections are laboratory confirmed, while differences in case definitions and approaches to case ascertainment can lead to wide variation in case fatality risk estimates. Serological surveillance can be used to estimate the cumulative incidence of infection as a denominator that is more comparable across studies. We estimated that the first wave of the influenza A(H1N1)pdm09 virus in 2009 was associated with approximately 232 (95% confidence interval: 136, 328) excess deaths of all ages in Hong Kong, mainly among the elderly. The point estimates of the risk of death on a per-infection basis increased substantially with age, from below 1 per 100,000 infections in children to 1,099 per 100,000 infections in those 60-69 years of age. Substantial variation in the age-specific infection fatality risk complicates comparison of the severity of different influenza strains. © 2013 The Author.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/-
dc.relation.ispartofAmerican Journal of Epidemiologyen_US
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Epidemiology following peer review. The definitive publisher-authenticated version American Journal of Epidemiology, 2013, v. 177 n. 8, p. 834-840 is available online at: http://aje.oxfordjournals.org/content/177/8/834-
dc.subjectdeath-
dc.subjecthuman influenza-
dc.subjectseverity-
dc.titleInfection fatality risk of the pandemic A(H1N1)2009 virus in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailWong, YT: wongytj@hku.hken_US
dc.identifier.emailWu, P: pengwu@hku.hken_US
dc.identifier.emailNishiura, H: nishiura@hku.hken_US
dc.identifier.emailLau, EHY: ehylau@hku.hken_US
dc.identifier.emailYang, L: linyang@hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailWu, JTK: joewu@hku.hken_US
dc.identifier.emailCowling, BJ: bcowling@hku.hken_US
dc.identifier.authorityNishiura, H=rp01488en_US
dc.identifier.authorityLau, EHY=rp01349en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityWu, JTK=rp00517en_US
dc.identifier.authorityCowling, BJ=rp01326en_US
dc.description.naturepostprint-
dc.identifier.doi10.1093/aje/kws314-
dc.identifier.pmid23459950-
dc.identifier.scopuseid_2-s2.0-84876272098-
dc.identifier.hkuros214718en_US
dc.identifier.volume177en_US
dc.identifier.issue8en_US
dc.identifier.spage834en_US
dc.identifier.epage40en_US
dc.identifier.eissn1476-6256-
dc.identifier.isiWOS:000317435600013-
dc.identifier.issnl0002-9262-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats