Investigation of Phellinus linteus mushroom extract on cell cycle of colon cancer cell LS 174T under oxidative stress challenge

Abstract

Phellinus linteus (PL) has traditionally been used as a medicinal mushroom in some countries such as China, Japan and Korea. It was found the fruiting body of PL is rich in bioactive phytochemicals. The antioxidant property of PL has been associated in preventing cancer progression. It is also suggested that the polysaccaharides component of PL is responsible for antitumor and immuno-modulatory effect in vivo and in vitro. However, the mechanism of the inhibition effect and invasive behavior of PL on cancer such as LS 174T colonic carcinoma is not well elucidated. PL is suggested to be able to inhibit cancer cell adhesion and invasion of the extracellular matrix. Therefore, it is believed that PL can exert antitumor effect by initiating apoptosis and cell cycle blockade in ...