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- Publisher Website: 10.1007/s00259-012-2091-2
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- PMID: 22532252
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Article: PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma
Title | PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma |
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Authors | |
Issue Date | 2012 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00259/index.htm |
Citation | European Journal of Nuclear Medicine and Molecular Imaging, 2012, v. 39 n. 7, p. 1097-1106 How to Cite? |
Abstract | PURPOSE: While FDG PET/CT for the evaluation of nasopharyngeal carcinoma (NPC) in adult patients has documented advantages and disadvantages compared with conventional imaging, to our knowledge, no studies of FDG PET/CT for the evaluation of NPC in pediatric patients have been performed. In this investigation, we studied the utility of FDG PET/CT in children with NPC. METHODS: The study group comprised 18 children with biopsy-proven NPC who underwent FDG PET/CT and MRI (total 38 pairs of images). All baseline and follow-up FDG PET/CT and MRI studies were independently reviewed for restaging of disease. RESULTS: The concordance between FDG PET/CT and MRI in T, N, and overall staging was 29%, 64%, and 43%, respectively. Compared with MRI, FDG PET/CT yielded lower T and overall staging and showed less cervical and retropharyngeal lymphadenopathy. The concordance between follow-up FDG PET/CT and MRI was 79% overall and 100% 9 months after therapy. In patients who achieved complete remission, FDG PET/CT showed disease clearance 3-6 months earlier than MRI. There were no false-positive or false-negative FDG PET/CT scans during follow-up. CONCLUSION: FDG PET/CT may underestimate tumor extent and regional lymphadenopathy compared with MRI at the time of diagnosis, but it helps to detect metastases and clarify ambiguous findings. FDG PET/CT is sensitive and specific for follow-up and enables earlier determination of disease remission. FDG PET/CT is a valuable imaging modality for the evaluation and monitoring of NPC in pediatric patients. |
Persistent Identifier | http://hdl.handle.net/10722/183769 |
ISSN | 2023 Impact Factor: 8.6 2023 SCImago Journal Rankings: 2.280 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheuk, DKL | - |
dc.contributor.author | Sabin, ND | - |
dc.contributor.author | Hossain, M | - |
dc.contributor.author | Wozniak, A | - |
dc.contributor.author | Naik, M | - |
dc.contributor.author | Rodriguez-Galindo, C | - |
dc.contributor.author | Krasin, MJ | - |
dc.contributor.author | Shulkin, BL | - |
dc.date.accessioned | 2013-06-18T04:13:39Z | - |
dc.date.available | 2013-06-18T04:13:39Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | European Journal of Nuclear Medicine and Molecular Imaging, 2012, v. 39 n. 7, p. 1097-1106 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | http://hdl.handle.net/10722/183769 | - |
dc.description.abstract | PURPOSE: While FDG PET/CT for the evaluation of nasopharyngeal carcinoma (NPC) in adult patients has documented advantages and disadvantages compared with conventional imaging, to our knowledge, no studies of FDG PET/CT for the evaluation of NPC in pediatric patients have been performed. In this investigation, we studied the utility of FDG PET/CT in children with NPC. METHODS: The study group comprised 18 children with biopsy-proven NPC who underwent FDG PET/CT and MRI (total 38 pairs of images). All baseline and follow-up FDG PET/CT and MRI studies were independently reviewed for restaging of disease. RESULTS: The concordance between FDG PET/CT and MRI in T, N, and overall staging was 29%, 64%, and 43%, respectively. Compared with MRI, FDG PET/CT yielded lower T and overall staging and showed less cervical and retropharyngeal lymphadenopathy. The concordance between follow-up FDG PET/CT and MRI was 79% overall and 100% 9 months after therapy. In patients who achieved complete remission, FDG PET/CT showed disease clearance 3-6 months earlier than MRI. There were no false-positive or false-negative FDG PET/CT scans during follow-up. CONCLUSION: FDG PET/CT may underestimate tumor extent and regional lymphadenopathy compared with MRI at the time of diagnosis, but it helps to detect metastases and clarify ambiguous findings. FDG PET/CT is sensitive and specific for follow-up and enables earlier determination of disease remission. FDG PET/CT is a valuable imaging modality for the evaluation and monitoring of NPC in pediatric patients. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00259/index.htm | - |
dc.relation.ispartof | European Journal of Nuclear Medicine and Molecular Imaging | - |
dc.subject.mesh | Fluorodeoxyglucose F18 - diagnostic use | - |
dc.subject.mesh | Magnetic Resonance Imaging - methods | - |
dc.subject.mesh | Nasopharyngeal Neoplasms - pathology - radionuclide imaging - therapy | - |
dc.subject.mesh | Positron-Emission Tomography and Computed Tomography - methods | - |
dc.subject.mesh | Radiopharmaceuticals - diagnostic use | - |
dc.title | PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Cheuk, DKL: klcheuk@HKUCC.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00259-012-2091-2 | - |
dc.identifier.pmid | 22532252 | - |
dc.identifier.pmcid | PMC3531235 | - |
dc.identifier.scopus | eid_2-s2.0-84862675257 | - |
dc.identifier.hkuros | 214768 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1097 | - |
dc.identifier.epage | 1106 | - |
dc.identifier.isi | WOS:000305215500002 | - |
dc.publisher.place | Germany | - |