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Article: The value of 18F-FDG PET/contrast-enhanced CT in detection of tumor thrombus
Title | The value of 18F-FDG PET/contrast-enhanced CT in detection of tumor thrombus |
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Authors | |
Keywords | 18F-FDG PET/ CT contrast-enhanced CT PET SUVmax tumor thrombosis |
Issue Date | 2013 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/ |
Citation | Clinical Nuclear Medicine, 2013, v. 38 n. 2, p. e60-e65 How to Cite? |
Abstract | PURPOSE: The differentiation between tumor and bland thromboses is important as the management differs. Retrospectively, we aim to evaluate the utility of FDG PET in detecting and differentiating tumor from bland thromboses and if FDG PET provides additional value to contrast-enhanced CT for tumor thrombus detection. PATIENTS AND METHODS: Twenty-four sites of venous thromboembolism, detected on PET/CT, were retrospectively reviewed. Classification of type of thrombosis was based on histology and radiological follow-up. We evaluated the presence of contrast-enhanced CT findings that were suggestive of tumor thrombosis; sign of invasion, neovascularity, and enhancement. Metabolic activity by means of SUV(max) was measured by drawing ROI at the site of thrombosis. Mann-Whitney U test was used to compare the mean SUV(max) between thromboses and internal references. We used ROC analysis to identify the optimal cutoff value of SUV(max) for detection of tumor thrombosis. RESULTS: Twenty-four sites of venous thromboembolism were identified in 15 patients. All tumor thromboses demonstrated at least 1 positive sign on contrast-enhanced CT, whereas 33% of bland thromboses had the same finding. The difference between tumor and bland thrombus SUV(max) was statistically significant (P < 0.005). On ROC analysis, a cutoff of SUV(max) 2.25 (sensitivity, 78%; specificity, 100%) was suggested to differentiate tumor from bland thrombosis. CONCLUSION: PET/CT is able to differentiate tumor from bland thrombosis, with an optimal cutoff value of SUV(max) 2.25. The metabolic information increases the diagnostic accuracy of tumor thrombus and is a useful adjunct to the described features on contrast-enhanced CT. |
Persistent Identifier | http://hdl.handle.net/10722/183717 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 0.571 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, EYP | en_US |
dc.contributor.author | Khong, PL | en_US |
dc.date.accessioned | 2013-06-18T04:09:55Z | - |
dc.date.available | 2013-06-18T04:09:55Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Clinical Nuclear Medicine, 2013, v. 38 n. 2, p. e60-e65 | en_US |
dc.identifier.issn | 0363-9762 | - |
dc.identifier.uri | http://hdl.handle.net/10722/183717 | - |
dc.description.abstract | PURPOSE: The differentiation between tumor and bland thromboses is important as the management differs. Retrospectively, we aim to evaluate the utility of FDG PET in detecting and differentiating tumor from bland thromboses and if FDG PET provides additional value to contrast-enhanced CT for tumor thrombus detection. PATIENTS AND METHODS: Twenty-four sites of venous thromboembolism, detected on PET/CT, were retrospectively reviewed. Classification of type of thrombosis was based on histology and radiological follow-up. We evaluated the presence of contrast-enhanced CT findings that were suggestive of tumor thrombosis; sign of invasion, neovascularity, and enhancement. Metabolic activity by means of SUV(max) was measured by drawing ROI at the site of thrombosis. Mann-Whitney U test was used to compare the mean SUV(max) between thromboses and internal references. We used ROC analysis to identify the optimal cutoff value of SUV(max) for detection of tumor thrombosis. RESULTS: Twenty-four sites of venous thromboembolism were identified in 15 patients. All tumor thromboses demonstrated at least 1 positive sign on contrast-enhanced CT, whereas 33% of bland thromboses had the same finding. The difference between tumor and bland thrombus SUV(max) was statistically significant (P < 0.005). On ROC analysis, a cutoff of SUV(max) 2.25 (sensitivity, 78%; specificity, 100%) was suggested to differentiate tumor from bland thrombosis. CONCLUSION: PET/CT is able to differentiate tumor from bland thrombosis, with an optimal cutoff value of SUV(max) 2.25. The metabolic information increases the diagnostic accuracy of tumor thrombus and is a useful adjunct to the described features on contrast-enhanced CT. | - |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/ | - |
dc.relation.ispartof | Clinical Nuclear Medicine | en_US |
dc.rights | This is a non-final version of an article published in final form in Clinical Nuclear Medicine, 2013, v. 38 n. 2, p. e60-e65 | - |
dc.subject | 18F-FDG PET/ CT | - |
dc.subject | contrast-enhanced CT | - |
dc.subject | PET | - |
dc.subject | SUVmax | - |
dc.subject | tumor thrombosis | - |
dc.subject.mesh | Contrast Media - diagnostic use | - |
dc.subject.mesh | Fluorodeoxyglucose F18 - diagnostic use | - |
dc.subject.mesh | Neoplasms - diagnosis - radiography - radionuclide imaging | - |
dc.subject.mesh | Positron-Emission Tomography | - |
dc.subject.mesh | Thrombosis - diagnosis - radiography - radionuclide imaging | - |
dc.title | The value of 18F-FDG PET/contrast-enhanced CT in detection of tumor thrombus | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, EYP: eyplee77@hku.hk | en_US |
dc.identifier.email | Khong, PL: plkhong@hkucc.hku.hk | en_US |
dc.identifier.authority | Lee, EYP=rp01456 | en_US |
dc.identifier.authority | Khong, PL=rp00467 | en_US |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1097/RLU.0b013e318266d53e | - |
dc.identifier.pmid | 23334142 | - |
dc.identifier.scopus | eid_2-s2.0-84872910500 | - |
dc.identifier.hkuros | 214902 | en_US |
dc.identifier.hkuros | 202461 | - |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | e60 | en_US |
dc.identifier.epage | e65 | en_US |
dc.identifier.isi | WOS:000313798100002 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0363-9762 | - |