File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Aortic distensibility and retinal arteriolar narrowing: The multi-ethnic study of atherosclerosis

TitleAortic distensibility and retinal arteriolar narrowing: The multi-ethnic study of atherosclerosis
Authors
KeywordsArterial compliance
Imaging
Microcirculation
Population science
Risk factors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 2007, v. 50 n. 4, p. 617-622 How to Cite?
AbstractIncreased aortic stiffness and retinal arteriolar narrowing are subclinical vascular effects of chronic hypertension and predict future cardiovascular events. The relationship between these 2 vascular measures is uncertain and is examined in the Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis involves 3425 participants (aged 45 to 85 years) free of clinical cardiovascular disease. Retinal vascular caliber was quantified from digital retinal photographs using standardized protocols. Aortic distensibility was determined from chest MRI. After controlling for age, squared age, gender, race, study center, height, weight, heart rate, cigarette smoking, past and current systolic blood pressure, use of antihypertensive medications, diabetes, fasting glucose, lipid profile, and C-reactive protein, reduced aortic distensibility (first versus fourth distensibility quartile) was associated with increased odds of retinal arteriolar narrowing (odds ratio: 1.72; 95% CI: 1.15 to 2.58, comparing lowest to highest quartile of arteriolar caliber). Further adjustments for atherosclerotic measures (carotid intima-media thickness, coronary calcium score, and ankle brachial index) had minimal impact on this association (odds ratio: 1.70; 95% CI: 1.13 to 2.55). Reduced aortic distensibility was not associated with retinal venular caliber. We conclude that increased aortic stiffness is associated with retinal arteriolar narrowing, independent of measured blood pressure levels and vascular risk factors. These data suggest that changes in the microvasculature may play a role linking aortic stiffness with clinical cardiovascular events. © 2007 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183530
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 2.827
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorCriqui, MHen_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorMacura, KJen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorKlein, BEKen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:27Z-
dc.date.available2013-05-28T06:14:27Z-
dc.date.issued2007en_US
dc.identifier.citationHypertension, 2007, v. 50 n. 4, p. 617-622en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/183530-
dc.description.abstractIncreased aortic stiffness and retinal arteriolar narrowing are subclinical vascular effects of chronic hypertension and predict future cardiovascular events. The relationship between these 2 vascular measures is uncertain and is examined in the Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis involves 3425 participants (aged 45 to 85 years) free of clinical cardiovascular disease. Retinal vascular caliber was quantified from digital retinal photographs using standardized protocols. Aortic distensibility was determined from chest MRI. After controlling for age, squared age, gender, race, study center, height, weight, heart rate, cigarette smoking, past and current systolic blood pressure, use of antihypertensive medications, diabetes, fasting glucose, lipid profile, and C-reactive protein, reduced aortic distensibility (first versus fourth distensibility quartile) was associated with increased odds of retinal arteriolar narrowing (odds ratio: 1.72; 95% CI: 1.15 to 2.58, comparing lowest to highest quartile of arteriolar caliber). Further adjustments for atherosclerotic measures (carotid intima-media thickness, coronary calcium score, and ankle brachial index) had minimal impact on this association (odds ratio: 1.70; 95% CI: 1.13 to 2.55). Reduced aortic distensibility was not associated with retinal venular caliber. We conclude that increased aortic stiffness is associated with retinal arteriolar narrowing, independent of measured blood pressure levels and vascular risk factors. These data suggest that changes in the microvasculature may play a role linking aortic stiffness with clinical cardiovascular events. © 2007 American Heart Association, Inc.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subjectArterial compliance-
dc.subjectImaging-
dc.subjectMicrocirculation-
dc.subjectPopulation science-
dc.subjectRisk factors-
dc.subject.meshAfrican Americansen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAorta - Pathology - Physiopathologyen_US
dc.subject.meshArterioles - Pathology - Physiopathologyen_US
dc.subject.meshAsian Americansen_US
dc.subject.meshAtherosclerosis - Ethnology - Etiology - Pathologyen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshElasticityen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshHispanic Americansen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Complications - Pathology - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculation - Pathology - Physiopathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetinal Artery - Pathology - Physiopathologyen_US
dc.subject.meshRisk Factorsen_US
dc.titleAortic distensibility and retinal arteriolar narrowing: The multi-ethnic study of atherosclerosisen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1161/HYPERTENSIONAHA.107.091926en_US
dc.identifier.pmid17698721-
dc.identifier.scopuseid_2-s2.0-34548857642en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548857642&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue4en_US
dc.identifier.spage617en_US
dc.identifier.epage622en_US
dc.identifier.isiWOS:000249586900008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridCriqui, MH=7005209601en_US
dc.identifier.scopusauthoridIslam, FMA=55399085000en_US
dc.identifier.scopusauthoridMacura, KJ=6603866653en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridKlein, BEK=35433541400en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US
dc.identifier.issnl0194-911X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats