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- Publisher Website: 10.1007/s10689-012-9531-9
- Scopus: eid_2-s2.0-84870424733
- PMID: 22638769
- WOS: WOS:000311025000016
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Article: Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
Title | Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations |
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Authors | |
Keywords | Brca1/2 Breast Cancer Race/Ethnicity Risk Factors Snps |
Issue Date | 2012 |
Publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1389-9600 |
Citation | Familial Cancer, 2012, v. 11 n. 3, p. 429-439 How to Cite? |
Abstract | The prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1/2 mutations and cancer risk factors in a clinic-based sample. BRCA1/2 mutation carriers were enrolled from cancer genetics clinics in Hong Kong and California according to standardized entry criteria. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. We performed logistic regression to identify independent predictors of breast cancer. Fifty Asian women and forty-nine white American women were enrolled. BRCA1 mutations were more common among whites (67 vs. 42 %, p = 0.02), and BRCA2 mutations among Asians (58 vs. 37 %, p = 0.04). More Asians had breast cancer (76 vs. 53 %, p = 0.03); more whites had relatives with breast cancer (86 vs. 50 %, p = 0.0003). More whites than Asians had breastfed (71 vs. 42 %, p = 0.005), had high BMI (median 24.3 vs. 21.2, p = 0.04), consumed alcohol (2 drinks/week vs. 0, p > 0.001), and had oophorectomy (61 vs. 34 %, p = 0.01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002). On logistic regression, MAP3K1 was associated with increased breast cancer risk for BRCA2, but not BRCA1 mutation carriers; breast density was associated with increased risk among Asians but not whites. We found significant differences in breast cancer risk factors between Asian and white BRCA1/2 mutation carriers. Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies. © Springer Science+Business Media B.V. 2012. |
Persistent Identifier | http://hdl.handle.net/10722/182365 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 1.016 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | De Bruin, MA | en_US |
dc.contributor.author | Kwong, A | en_US |
dc.contributor.author | Goldstein, BA | en_US |
dc.contributor.author | Lipson, JA | en_US |
dc.contributor.author | Ikeda, DM | en_US |
dc.contributor.author | Mcpherson, L | en_US |
dc.contributor.author | Sharma, B | en_US |
dc.contributor.author | Kardashian, A | en_US |
dc.contributor.author | Schackmann, E | en_US |
dc.contributor.author | Kingham, KE | en_US |
dc.contributor.author | Mills, MA | en_US |
dc.contributor.author | West, DW | en_US |
dc.contributor.author | Ford, JM | en_US |
dc.contributor.author | Kurian, AW | en_US |
dc.date.accessioned | 2013-04-23T08:20:22Z | - |
dc.date.available | 2013-04-23T08:20:22Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Familial Cancer, 2012, v. 11 n. 3, p. 429-439 | en_US |
dc.identifier.issn | 1389-9600 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/182365 | - |
dc.description.abstract | The prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1/2 mutations and cancer risk factors in a clinic-based sample. BRCA1/2 mutation carriers were enrolled from cancer genetics clinics in Hong Kong and California according to standardized entry criteria. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. We performed logistic regression to identify independent predictors of breast cancer. Fifty Asian women and forty-nine white American women were enrolled. BRCA1 mutations were more common among whites (67 vs. 42 %, p = 0.02), and BRCA2 mutations among Asians (58 vs. 37 %, p = 0.04). More Asians had breast cancer (76 vs. 53 %, p = 0.03); more whites had relatives with breast cancer (86 vs. 50 %, p = 0.0003). More whites than Asians had breastfed (71 vs. 42 %, p = 0.005), had high BMI (median 24.3 vs. 21.2, p = 0.04), consumed alcohol (2 drinks/week vs. 0, p > 0.001), and had oophorectomy (61 vs. 34 %, p = 0.01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002). On logistic regression, MAP3K1 was associated with increased breast cancer risk for BRCA2, but not BRCA1 mutation carriers; breast density was associated with increased risk among Asians but not whites. We found significant differences in breast cancer risk factors between Asian and white BRCA1/2 mutation carriers. Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies. © Springer Science+Business Media B.V. 2012. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1389-9600 | en_US |
dc.relation.ispartof | Familial Cancer | en_US |
dc.rights | The original publication is available at www.springerlink.com | - |
dc.subject | Brca1/2 | en_US |
dc.subject | Breast Cancer | en_US |
dc.subject | Race/Ethnicity | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Snps | en_US |
dc.title | Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations | en_US |
dc.type | Article | en_US |
dc.identifier.email | Kwong, A: avakwong@hkucc.hku.hk | en_US |
dc.identifier.authority | Kwong, A=rp01734 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s10689-012-9531-9 | en_US |
dc.identifier.pmid | 22638769 | - |
dc.identifier.scopus | eid_2-s2.0-84870424733 | en_US |
dc.identifier.hkuros | 212682 | - |
dc.identifier.hkuros | 216912 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84870424733&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 429 | en_US |
dc.identifier.epage | 439 | en_US |
dc.identifier.isi | WOS:000311025000016 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | De Bruin, MA=55356260500 | en_US |
dc.identifier.scopusauthorid | Kwong, A=8913654300 | en_US |
dc.identifier.scopusauthorid | Goldstein, BA=55503811400 | en_US |
dc.identifier.scopusauthorid | Lipson, JA=7006318468 | en_US |
dc.identifier.scopusauthorid | Ikeda, DM=55421397400 | en_US |
dc.identifier.scopusauthorid | McPherson, L=7004681320 | en_US |
dc.identifier.scopusauthorid | Sharma, B=55509102700 | en_US |
dc.identifier.scopusauthorid | Kardashian, A=55248226400 | en_US |
dc.identifier.scopusauthorid | Schackmann, E=55272505300 | en_US |
dc.identifier.scopusauthorid | Kingham, KE=6601960896 | en_US |
dc.identifier.scopusauthorid | Mills, MA=7201488233 | en_US |
dc.identifier.scopusauthorid | West, DW=7401998438 | en_US |
dc.identifier.scopusauthorid | Ford, JM=7402915714 | en_US |
dc.identifier.scopusauthorid | Kurian, AW=6701674280 | en_US |
dc.identifier.issnl | 1389-9600 | - |