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- Publisher Website: 10.1159/000151332
- Scopus: eid_2-s2.0-50049103153
- PMID: 18753751
- WOS: WOS:000259726100002
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Article: A prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening result
Title | A prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening result |
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Authors | |
Keywords | Aneuploidy testing Anxiety Down syndrome Karyotyping |
Issue Date | 2008 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/FDT |
Citation | Fetal Diagnosis And Therapy, 2008, v. 24 n. 3, p. 165-169 How to Cite? |
Abstract | Objectives: To examine the effect of rapid aneuploidy testing by amnio-PCR on anxiety levels and quality of life measures in women and their partners with positive Down screening result. Methods: In the original design, screen-positive women were to be randomized to have amnio-PCR or not. Of the first 60 women approached to join the study between April 2004 and April 2005, 4 declined amniocentesis, 14 agreed to be randomized, while the other 42 (75%) chose to pay for the amnio-PCR themselves (3 excluded: 2 because of Down syndrome and 1 dropout). The study was thus performed as a prospective observational study on the remaining 39 women of the last group. The longitudinal profile of the state-anxiety and quality of life domain scores for this cohort were studied using the Spielberger State-Trait Anxiety Inventory and WHO Quality of Life Measure - abbreviated version (Hong Kong) Questionnaire at 5 time points: (1) before amniocentesis, (2) 2 days after amniocentesis when amnio-PCR report was disclosed, (3) 3 weeks after amniocentesis when karyotyping report was disclosed, (4) 30-32 weeks' gestation, (5) 6 weeks after delivery. Results: In the final cohort of 39 women and 27 partners, a significant reduction in their state-anxiety scores was found when they received the normal amnio-PCR report. On the other hand, there was no significant change in their quality of life domain scores. Conclusions: There is a demand from women and their partners who had a positive Down screening result for rapid aneuploidy testing (amnio-PCR) which can effectively alleviate their anxiety. A rapid aneuploidy test should be made available to women in a Down screening programme. Copyright © 2008 S. Karger AG. |
Persistent Identifier | http://hdl.handle.net/10722/180690 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.767 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, WC | en_US |
dc.contributor.author | Lau, ET | en_US |
dc.contributor.author | Ngai, C | en_US |
dc.contributor.author | Lam, H | en_US |
dc.contributor.author | Leung, KY | en_US |
dc.contributor.author | Lee, CP | en_US |
dc.contributor.author | Lao, TT | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.date.accessioned | 2013-01-28T01:41:08Z | - |
dc.date.available | 2013-01-28T01:41:08Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Fetal Diagnosis And Therapy, 2008, v. 24 n. 3, p. 165-169 | en_US |
dc.identifier.issn | 1015-3837 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180690 | - |
dc.description.abstract | Objectives: To examine the effect of rapid aneuploidy testing by amnio-PCR on anxiety levels and quality of life measures in women and their partners with positive Down screening result. Methods: In the original design, screen-positive women were to be randomized to have amnio-PCR or not. Of the first 60 women approached to join the study between April 2004 and April 2005, 4 declined amniocentesis, 14 agreed to be randomized, while the other 42 (75%) chose to pay for the amnio-PCR themselves (3 excluded: 2 because of Down syndrome and 1 dropout). The study was thus performed as a prospective observational study on the remaining 39 women of the last group. The longitudinal profile of the state-anxiety and quality of life domain scores for this cohort were studied using the Spielberger State-Trait Anxiety Inventory and WHO Quality of Life Measure - abbreviated version (Hong Kong) Questionnaire at 5 time points: (1) before amniocentesis, (2) 2 days after amniocentesis when amnio-PCR report was disclosed, (3) 3 weeks after amniocentesis when karyotyping report was disclosed, (4) 30-32 weeks' gestation, (5) 6 weeks after delivery. Results: In the final cohort of 39 women and 27 partners, a significant reduction in their state-anxiety scores was found when they received the normal amnio-PCR report. On the other hand, there was no significant change in their quality of life domain scores. Conclusions: There is a demand from women and their partners who had a positive Down screening result for rapid aneuploidy testing (amnio-PCR) which can effectively alleviate their anxiety. A rapid aneuploidy test should be made available to women in a Down screening programme. Copyright © 2008 S. Karger AG. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/FDT | en_US |
dc.relation.ispartof | Fetal Diagnosis and Therapy | en_US |
dc.subject | Aneuploidy testing | - |
dc.subject | Anxiety | - |
dc.subject | Down syndrome | - |
dc.subject | Karyotyping | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Amniocentesis - Psychology | en_US |
dc.subject.mesh | Anxiety | en_US |
dc.subject.mesh | Cohort Studies | en_US |
dc.subject.mesh | Down Syndrome - Diagnosis - Genetics - Psychology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Diagnosis - Genetics - Psychology | en_US |
dc.subject.mesh | Genetic Testing - Psychology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Karyotyping | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Quality Of Life | en_US |
dc.title | A prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening result | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000151332 | en_US |
dc.identifier.pmid | 18753751 | - |
dc.identifier.scopus | eid_2-s2.0-50049103153 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-50049103153&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 165 | en_US |
dc.identifier.epage | 169 | en_US |
dc.identifier.isi | WOS:000259726100002 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Leung, WC=7201504435 | en_US |
dc.identifier.scopusauthorid | Lau, ET=36006491400 | en_US |
dc.identifier.scopusauthorid | Ngai, C=6603676357 | en_US |
dc.identifier.scopusauthorid | Lam, H=16022602300 | en_US |
dc.identifier.scopusauthorid | Leung, KY=8247106900 | en_US |
dc.identifier.scopusauthorid | Lee, CP=7410141601 | en_US |
dc.identifier.scopusauthorid | Lao, TT=35327208900 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.issnl | 1015-3837 | - |