File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.neubiorev.2012.11.001
- Scopus: eid_2-s2.0-84875061874
- PMID: 23153795
- WOS: WOS:000316586700001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Cytokines: how important are they in mediating sickness?
Title | Cytokines: how important are they in mediating sickness? |
---|---|
Authors | |
Keywords | Cytokines Delirium Sickness Systemic inflammation |
Issue Date | 2013 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev |
Citation | Neuroscience & Biobehavioral Reviews, 2013, v. 37 n. 1, p. 1-10 How to Cite? |
Abstract | Sickness refers to a set of coordinated physiological and behavioral changes in response to systemic inflammation. It is characterized by fever, malaise, social withdrawal, fatigue, and anorexia. While these responses collectively represent a protective mechanism against infection and injury, increasing lines of evidence indicate that over-exaggerated or persistent sickness can damage the brain, and could possibly raise the risk to developing delirium. Therefore, a clear understanding in sickness will be beneficial. It has long been believed that sickness results from increased systemic cytokines occurring during systemic inflammation. However, in recent years more and more conflicting data have suggested that development of sickness following peripheral immune challenge could be independent of cytokines. Hence, it is confusing as to whether cytokines really do act as primary mediators of sickness, or if they are secondary to alternative inducing factor(s). In this review, we will (1) introduce the relationships between systemic inflammation, cytokines, sickness, and delirium, and (2) attempt to interpret the recent controversies. |
Persistent Identifier | http://hdl.handle.net/10722/180128 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.810 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Poon, DCH | en_US |
dc.contributor.author | Ho, YS | en_US |
dc.contributor.author | Chiu, K | en_US |
dc.contributor.author | Chang, RCC | en_US |
dc.date.accessioned | 2013-01-21T01:29:12Z | - |
dc.date.available | 2013-01-21T01:29:12Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Neuroscience & Biobehavioral Reviews, 2013, v. 37 n. 1, p. 1-10 | en_US |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | http://hdl.handle.net/10722/180128 | - |
dc.description.abstract | Sickness refers to a set of coordinated physiological and behavioral changes in response to systemic inflammation. It is characterized by fever, malaise, social withdrawal, fatigue, and anorexia. While these responses collectively represent a protective mechanism against infection and injury, increasing lines of evidence indicate that over-exaggerated or persistent sickness can damage the brain, and could possibly raise the risk to developing delirium. Therefore, a clear understanding in sickness will be beneficial. It has long been believed that sickness results from increased systemic cytokines occurring during systemic inflammation. However, in recent years more and more conflicting data have suggested that development of sickness following peripheral immune challenge could be independent of cytokines. Hence, it is confusing as to whether cytokines really do act as primary mediators of sickness, or if they are secondary to alternative inducing factor(s). In this review, we will (1) introduce the relationships between systemic inflammation, cytokines, sickness, and delirium, and (2) attempt to interpret the recent controversies. | - |
dc.language | eng | en_US |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev | - |
dc.relation.ispartof | Neuroscience & Biobehavioral Reviews | en_US |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in Neuroscience & Biobehavioral Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroscience & Biobehavioral Reviews, 2013, v. 37 n. 1, p. 1-10. DOI: 10.1016/j.neubiorev.2012.11.001 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cytokines | - |
dc.subject | Delirium | - |
dc.subject | Sickness | - |
dc.subject | Systemic inflammation | - |
dc.subject.mesh | Brain - physiology | - |
dc.subject.mesh | Cytokines - physiology | - |
dc.subject.mesh | Delirium - physiopathology | - |
dc.subject.mesh | Illness Behavior - physiology | - |
dc.subject.mesh | Inflammation - physiopathology | - |
dc.title | Cytokines: how important are they in mediating sickness? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ho, YS: janiceys@hku.hk | en_US |
dc.identifier.email | Chiu, K: datwai@hkucc.hku.hk | en_US |
dc.identifier.email | Chang, RCC: rccchang@hku.hk | en_US |
dc.identifier.authority | Chang, RCC=rp00470 | en_US |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.neubiorev.2012.11.001 | - |
dc.identifier.pmid | 23153795 | - |
dc.identifier.scopus | eid_2-s2.0-84875061874 | - |
dc.identifier.hkuros | 212923 | en_US |
dc.identifier.hkuros | 276811 | - |
dc.identifier.volume | 37 | en_US |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 10 | en_US |
dc.identifier.isi | WOS:000316586700001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0149-7634 | - |